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| Main Authors: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
mLife
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40313977/ |
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Table of Contents:
- An archaeal virus capable of hydrolyzing the surface glycan of the host cell. Yuan, Wanjuan Pei, Caixia Huang, Junkai Chen, Hongyu Fan, Juanying Jin, Cheng Huang, Li Spindle-shaped viruses exclusively infect archaea. Fuselloviruses represent a large group of spindle-shaped viruses and infect hyperthermophilic archaea of the order . Although the first fusellovirus was identified nearly 40 years ago, the mechanism of host infection by these viruses remains poorly understood. Here, we show that SSV19, a fusellovirus isolated from a hot spring in the Philippines, is capable of hydrolyzing the host cell surface glycan identified as a heptasaccharide chain of QuiSHexHexNAc. Our findings provide significant insights into the molecular strategy of host recognition and, possibly, entry by an archaeal virus.