epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs.
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| Natura: | Artículo científico |
| Lingua: | en |
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eLife
2025
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| author | Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z |
| author_facet | Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z |
| collection | PubMed - marine biology |
| contents | epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z Animals Nociception Nociceptors Mechanotransduction, Cellular Drosophila melanogaster Epidermal Cells Behavior, Animal Drosophila Proteins Larva Drosophila Somatosensory neurons (SSNs) that detect and transduce mechanical, thermal, and chemical stimuli densely innervate an animal's skin. However, although epidermal cells provide the first point of contact for sensory stimuli, our understanding of roles that epidermal cells play in SSN function, particularly nociception, remains limited. Here, we show that stimulating epidermal cells elicits activation of SSNs including nociceptors and triggers a variety of behavior outputs, including avoidance and escape. Further, we find that epidermal cells are intrinsically mechanosensitive and that epidermal mechanically evoked calcium responses require the store-operated calcium channel Orai. Epidermal cell stimulation augments larval responses to acute nociceptive stimuli and promotes prolonged hypersensitivity to subsequent mechanical stimuli. Hence, epidermal cells are key determinants of nociceptive sensitivity and sensitization, acting as primary sensors of noxious stimuli that tune nociceptor output and drive protective behaviors. |
| format | Artículo científico |
| id | pubmed_40353351 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | eLife |
| record_format | pubmed |
| spellingShingle | epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z Animals Nociception Nociceptors Mechanotransduction, Cellular Drosophila melanogaster Epidermal Cells Behavior, Animal Drosophila Proteins Larva Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Yoshino, Jiro Mali, Sonali S Williams, Claire R Morita, Takeshi Emerson, Chloe E Arp, Christopher J Miller, Sophie E Yin, Chang Thé, Lydia Hemmi, Chikayo Motoyoshi, Mana Ishii, Kenichi Emoto, Kazuo Bautista, Diana M Parrish, Jay Z Animals Nociception Nociceptors Mechanotransduction, Cellular Drosophila melanogaster Epidermal Cells Behavior, Animal Drosophila Proteins Larva Drosophila Somatosensory neurons (SSNs) that detect and transduce mechanical, thermal, and chemical stimuli densely innervate an animal's skin. However, although epidermal cells provide the first point of contact for sensory stimuli, our understanding of roles that epidermal cells play in SSN function, particularly nociception, remains limited. Here, we show that stimulating epidermal cells elicits activation of SSNs including nociceptors and triggers a variety of behavior outputs, including avoidance and escape. Further, we find that epidermal cells are intrinsically mechanosensitive and that epidermal mechanically evoked calcium responses require the store-operated calcium channel Orai. Epidermal cell stimulation augments larval responses to acute nociceptive stimuli and promotes prolonged hypersensitivity to subsequent mechanical stimuli. Hence, epidermal cells are key determinants of nociceptive sensitivity and sensitization, acting as primary sensors of noxious stimuli that tune nociceptor output and drive protective behaviors. |
| title | epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. |
| topic | Animals Nociception Nociceptors Mechanotransduction, Cellular Drosophila melanogaster Epidermal Cells Behavior, Animal Drosophila Proteins Larva Drosophila |
| url | https://pubmed.ncbi.nlm.nih.gov/40353351/ |