Evaluating the impact of Pomalidomide on memory dysfunction induced by neuroinflammation in Pentylenetetrazole-seizure model of male Wistar rats.
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| Format: | Artículo científico |
| Langue: | en |
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Metabolic brain disease
2025
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| author | Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid |
| author_facet | Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid |
| collection | PubMed - marine biology |
| contents | Evaluating the impact of Pomalidomide on memory dysfunction induced by neuroinflammation in Pentylenetetrazole-seizure model of male Wistar rats. Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid Animals Thalidomide Rats, Wistar Male Pentylenetetrazole Rats Seizures Memory Disorders Neuroinflammatory Diseases Disease Models, Animal Anti-Inflammatory Agents Avoidance Learning Hippocampus Neuroinflammation, a consequence and cause of epileptic seizures, is one of the leading causes of memory dysfunction in epileptic patients. The; current study evaluated Pomalidomide's; (POM) anti-inflammatory effect on passive avoidance memory impairments caused by Pentylenetetrazole-induced seizure in male Wistar rats. Rats were grouped into five groups, including control, Pentylenetetrazole (PTZ), and treatment groups. Three groups were pretreated with different doses of Pomalidomide (25, 50, and 100 mg/kg) before PTZ 70 (mg/kg). The Shuttle box test was utilized to examine passive avoidance memory and learning. Finally, brain samples were prepared under deep anesthesia and used for histological observation and gene expression studies. Based on data analysis Pomalidomide -pretreated groups showed better memory performance than either the control or the PTZ group (P |
| format | Artículo científico |
| id | pubmed_40358812 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Metabolic brain disease |
| record_format | pubmed |
| spellingShingle | Evaluating the impact of Pomalidomide on memory dysfunction induced by neuroinflammation in Pentylenetetrazole-seizure model of male Wistar rats. Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid Animals Thalidomide Rats, Wistar Male Pentylenetetrazole Rats Seizures Memory Disorders Neuroinflammatory Diseases Disease Models, Animal Anti-Inflammatory Agents Avoidance Learning Hippocampus Evaluating the impact of Pomalidomide on memory dysfunction induced by neuroinflammation in Pentylenetetrazole-seizure model of male Wistar rats. Khorasanian, Elnaz Rajabi-Maham, Hassan Hosseini, Abdolkarim Azizi, Vahid Animals Thalidomide Rats, Wistar Male Pentylenetetrazole Rats Seizures Memory Disorders Neuroinflammatory Diseases Disease Models, Animal Anti-Inflammatory Agents Avoidance Learning Hippocampus Neuroinflammation, a consequence and cause of epileptic seizures, is one of the leading causes of memory dysfunction in epileptic patients. The; current study evaluated Pomalidomide's; (POM) anti-inflammatory effect on passive avoidance memory impairments caused by Pentylenetetrazole-induced seizure in male Wistar rats. Rats were grouped into five groups, including control, Pentylenetetrazole (PTZ), and treatment groups. Three groups were pretreated with different doses of Pomalidomide (25, 50, and 100 mg/kg) before PTZ 70 (mg/kg). The Shuttle box test was utilized to examine passive avoidance memory and learning. Finally, brain samples were prepared under deep anesthesia and used for histological observation and gene expression studies. Based on data analysis Pomalidomide -pretreated groups showed better memory performance than either the control or the PTZ group (P |
| title | Evaluating the impact of Pomalidomide on memory dysfunction induced by neuroinflammation in Pentylenetetrazole-seizure model of male Wistar rats. |
| topic | Animals Thalidomide Rats, Wistar Male Pentylenetetrazole Rats Seizures Memory Disorders Neuroinflammatory Diseases Disease Models, Animal Anti-Inflammatory Agents Avoidance Learning Hippocampus |
| url | https://pubmed.ncbi.nlm.nih.gov/40358812/ |