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| Auteurs principaux: | , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Molecules (Basel, Switzerland)
2025
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| Sujets: | |
| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/40363810/ |
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| _version_ | 1868266204009857025 |
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| author | Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai |
| author_facet | Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai |
| collection | PubMed - marine biology |
| contents | Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics. Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai Animals Mice Metabolomics Muscular Atrophy Muscle, Skeletal Physical Conditioning, Animal Aging Magnetic Resonance Spectroscopy Male Metabolome Disease Models, Animal Metabolic Networks and Pathways Age-related skeletal muscle atrophy is a major health concern in the elderly, contributing to reduced mobility, increased risk of falls, and metabolic dysfunction. The senescence-accelerated prone 8 (SAMP8) mouse model, known for its rapid aging and early cognitive decline, serves as an essential model for studying age-related muscle degeneration. While previous studies have shown that exercise attenuates muscle atrophy by promoting regeneration and improving strength, the underlying metabolic mechanisms remain poorly understood. This study used the SAMP8 model to evaluate the effects of exercise on muscle atrophy and associated metabolic changes. Our results show that exercise promoted muscle growth by reducing body weight, increasing skeletal muscle mass, and decreasing fat accumulation. Furthermore, exercise improved grip strength, muscle tone, and muscle fiber cross-sectional area, thereby preserving muscle functionality. NMR-based metabolomic analysis identified key metabolic pathways modulated by exercise, including glycine, serine, and threonine metabolism; alanine, aspartate, and glutamate metabolism; pyruvate metabolism; and taurine and hypotaurine metabolism. These findings underscore the therapeutic potential of exercise in combating age-related muscle wasting and elucidate the metabolic pathways underlying its benefits. |
| format | Artículo científico |
| id | pubmed_40363810 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecules (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics. Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai Animals Mice Metabolomics Muscular Atrophy Muscle, Skeletal Physical Conditioning, Animal Aging Magnetic Resonance Spectroscopy Male Metabolome Disease Models, Animal Metabolic Networks and Pathways Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics. Wu, Wenfang Zhang, Linglin Chen, Yifen Huang, Caihua Yang, Longhe Lin, Donghai Animals Mice Metabolomics Muscular Atrophy Muscle, Skeletal Physical Conditioning, Animal Aging Magnetic Resonance Spectroscopy Male Metabolome Disease Models, Animal Metabolic Networks and Pathways Age-related skeletal muscle atrophy is a major health concern in the elderly, contributing to reduced mobility, increased risk of falls, and metabolic dysfunction. The senescence-accelerated prone 8 (SAMP8) mouse model, known for its rapid aging and early cognitive decline, serves as an essential model for studying age-related muscle degeneration. While previous studies have shown that exercise attenuates muscle atrophy by promoting regeneration and improving strength, the underlying metabolic mechanisms remain poorly understood. This study used the SAMP8 model to evaluate the effects of exercise on muscle atrophy and associated metabolic changes. Our results show that exercise promoted muscle growth by reducing body weight, increasing skeletal muscle mass, and decreasing fat accumulation. Furthermore, exercise improved grip strength, muscle tone, and muscle fiber cross-sectional area, thereby preserving muscle functionality. NMR-based metabolomic analysis identified key metabolic pathways modulated by exercise, including glycine, serine, and threonine metabolism; alanine, aspartate, and glutamate metabolism; pyruvate metabolism; and taurine and hypotaurine metabolism. These findings underscore the therapeutic potential of exercise in combating age-related muscle wasting and elucidate the metabolic pathways underlying its benefits. |
| title | Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics. |
| topic | Animals Mice Metabolomics Muscular Atrophy Muscle, Skeletal Physical Conditioning, Animal Aging Magnetic Resonance Spectroscopy Male Metabolome Disease Models, Animal Metabolic Networks and Pathways |
| url | https://pubmed.ncbi.nlm.nih.gov/40363810/ |