Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations.
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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Ecotoxicology and environmental safety
2025
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| _version_ | 1868266203998322689 |
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| author | Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo |
| author_facet | Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo |
| collection | PubMed - marine biology |
| contents | Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations. Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo Animals Water Pollutants, Chemical DNA Methylation Gadiformes Environmental Monitoring Epigenesis, Genetic Microplastics Arsenic Exposure to pollutants such as non-essential metals and microplastics can have harmful consequences for marine organisms. Detecting the impact of pollutants in wild populations can be especially challenging. Such environmental disturbances might prompt rapid responses in the affected organisms, generating changes in their gene expression mediated by epigenetic regulation. Here we use an epiRADseq approach to determine the effect of four non-essential metals (As, Cd, Hg, Pb) and microplastics (MP) on the methylation pattern of Benguela hake, Merluccius polli, captured in the FAO fishing area 34, along the coasts of Mauritania and Senegal. We analysed 49 hake specimens and generated 44,201 epigenetic loci. Despite moderate levels of pollution identified from tissue analysis, we found significant differentially methylated loci associated with the level of the five pollutants analysed (119 significant loci for As, 134 for Cd, 92 for Hg, 119 for Pb, and 159 for microplastics). Elevated Pb was significantly associated with a reduction in hake condition factor. Differentially methylated loci were associated with diverse pathways associated to responses for all pollutants (e.g. immune response, gene expression regulation), pointing to signs of stress within the population. It is worth noting that all pollutants were differentially methylated for a locus in NLRC3, previously associated with innate immune response in fishes. Overall, we found evidence of the effects of moderate concentration of pollutants in the methylation pattern in wild populations of M. polli. |
| format | Artículo científico |
| id | pubmed_40373707 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Ecotoxicology and environmental safety |
| record_format | pubmed |
| spellingShingle | Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations. Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo Animals Water Pollutants, Chemical DNA Methylation Gadiformes Environmental Monitoring Epigenesis, Genetic Microplastics Arsenic Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations. Blanco-Fernandez, Carmen Bobes-Villa, María López, Ainhoa Menéndez, Daniel Elmer, Kathryn R Garcia-Vazquez, Eva Machado-Schiaffino, Gonzalo Animals Water Pollutants, Chemical DNA Methylation Gadiformes Environmental Monitoring Epigenesis, Genetic Microplastics Arsenic Exposure to pollutants such as non-essential metals and microplastics can have harmful consequences for marine organisms. Detecting the impact of pollutants in wild populations can be especially challenging. Such environmental disturbances might prompt rapid responses in the affected organisms, generating changes in their gene expression mediated by epigenetic regulation. Here we use an epiRADseq approach to determine the effect of four non-essential metals (As, Cd, Hg, Pb) and microplastics (MP) on the methylation pattern of Benguela hake, Merluccius polli, captured in the FAO fishing area 34, along the coasts of Mauritania and Senegal. We analysed 49 hake specimens and generated 44,201 epigenetic loci. Despite moderate levels of pollution identified from tissue analysis, we found significant differentially methylated loci associated with the level of the five pollutants analysed (119 significant loci for As, 134 for Cd, 92 for Hg, 119 for Pb, and 159 for microplastics). Elevated Pb was significantly associated with a reduction in hake condition factor. Differentially methylated loci were associated with diverse pathways associated to responses for all pollutants (e.g. immune response, gene expression regulation), pointing to signs of stress within the population. It is worth noting that all pollutants were differentially methylated for a locus in NLRC3, previously associated with innate immune response in fishes. Overall, we found evidence of the effects of moderate concentration of pollutants in the methylation pattern in wild populations of M. polli. |
| title | Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations. |
| topic | Animals Water Pollutants, Chemical DNA Methylation Gadiformes Environmental Monitoring Epigenesis, Genetic Microplastics Arsenic |
| url | https://pubmed.ncbi.nlm.nih.gov/40373707/ |