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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Acta parasitologica
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40377774/ |
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| _version_ | 1868266203990982658 |
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| author | Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I |
| author_facet | Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I |
| collection | PubMed - marine biology |
| contents | Oral Treatment of Lactoferrin Nanocapsules Modulates the Immune Response of Mice to a Cryptosporidiosis Infection. Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I Animals Lactoferrin Mice Cryptosporidiosis Male Administration, Oral Feces Nanocapsules Cytokines Thiazoles Disease Models, Animal Nitro Compounds The current study was to evaluate the immunomodulatory impact of either lactoferrin (LF), lactoferrin nanocapsule (LF-NC), or lactoferrin conjugation with nanazoxid (NZ). Moreover, identifying drugs can effectively eliminate and successfully treat the infection with Cryptosporidium. Sixty male Swiss albino mice were divided into six groups, each of 10 mice. G1 served as the control, and G2 was inoculated with 10 oocysts. Mice were orally administered NZ (200 mg/kg b.wt.), LF (150 µg/kg b.wt.), or LF-NC (150 mg/kg b.wt./day) for a period of six days post-infection. The immunomodulatory potential and drug efficacy were assessed by fecal and intestinal oocyst counts, measuring antioxidant activities and cytokine levels in addition. Intestinal tissues were examined histopathologically. The cytokines TGF-β, INF-γ, and IL-10 were increased during infection and decreased following therapy. Mutually, the quantity of pathological lesions and oocysts in the ileal tissues was significantly diminished with the NZ plus LF-NC treatment. In addition, a considerable reduction of both fecal and intestinal samples, as well as a notable deterioration in oocyst counts, suggested that treatment with NZ alone or in combination with LF-NC was more effective. LF or LF-NC was found to exert a potent immunomodulatory effect on infected mice as well as minimize pathological lesions. This therapy approaches a successful therapeutic alternative for the treatment of cryptosporidiosis with few adverse effects. |
| format | Artículo científico |
| id | pubmed_40377774 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Acta parasitologica |
| record_format | pubmed |
| spellingShingle | Oral Treatment of Lactoferrin Nanocapsules Modulates the Immune Response of Mice to a Cryptosporidiosis Infection. Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I Animals Lactoferrin Mice Cryptosporidiosis Male Administration, Oral Feces Nanocapsules Cytokines Thiazoles Disease Models, Animal Nitro Compounds Oral Treatment of Lactoferrin Nanocapsules Modulates the Immune Response of Mice to a Cryptosporidiosis Infection. Aly, Ibrahim Elawamy, Waleed E Hamza, Hanan T El-Wahsh, Hany M El-Bahiry, Ahmed Matter, Amira Bakr, Lamia I Animals Lactoferrin Mice Cryptosporidiosis Male Administration, Oral Feces Nanocapsules Cytokines Thiazoles Disease Models, Animal Nitro Compounds The current study was to evaluate the immunomodulatory impact of either lactoferrin (LF), lactoferrin nanocapsule (LF-NC), or lactoferrin conjugation with nanazoxid (NZ). Moreover, identifying drugs can effectively eliminate and successfully treat the infection with Cryptosporidium. Sixty male Swiss albino mice were divided into six groups, each of 10 mice. G1 served as the control, and G2 was inoculated with 10 oocysts. Mice were orally administered NZ (200 mg/kg b.wt.), LF (150 µg/kg b.wt.), or LF-NC (150 mg/kg b.wt./day) for a period of six days post-infection. The immunomodulatory potential and drug efficacy were assessed by fecal and intestinal oocyst counts, measuring antioxidant activities and cytokine levels in addition. Intestinal tissues were examined histopathologically. The cytokines TGF-β, INF-γ, and IL-10 were increased during infection and decreased following therapy. Mutually, the quantity of pathological lesions and oocysts in the ileal tissues was significantly diminished with the NZ plus LF-NC treatment. In addition, a considerable reduction of both fecal and intestinal samples, as well as a notable deterioration in oocyst counts, suggested that treatment with NZ alone or in combination with LF-NC was more effective. LF or LF-NC was found to exert a potent immunomodulatory effect on infected mice as well as minimize pathological lesions. This therapy approaches a successful therapeutic alternative for the treatment of cryptosporidiosis with few adverse effects. |
| title | Oral Treatment of Lactoferrin Nanocapsules Modulates the Immune Response of Mice to a Cryptosporidiosis Infection. |
| topic | Animals Lactoferrin Mice Cryptosporidiosis Male Administration, Oral Feces Nanocapsules Cytokines Thiazoles Disease Models, Animal Nitro Compounds |
| url | https://pubmed.ncbi.nlm.nih.gov/40377774/ |