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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40378337/ |
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Table of Contents:
- Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine sp. Cyanobacterium. Niiyama, Mizuho Kurisawa, Naoaki Umeda, Kairi Jeelani, Ghulam Agusta, Adnan Luthfi Nozaki, Tomoyoshi Suenaga, Kiyotake Lipopeptides Plasmodium falciparum Humans Cyanobacteria Molecular Structure HeLa Cells Trypanosoma brucei rhodesiense Antiparasitic Agents Marine Biology Inhibitory Concentration 50 Ouhanamide (), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide () showed selective antiparasitic activity (IC = 1.2 ± 0.1 μM against and IC = 4.2 ± 0.9 μM against ) without cytotoxicity at 10 μM against HeLa cells.