Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.

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Bibliographic Details
Main Authors:	Chen, Xiaohui, Li, Rongna, Qiu, Yingkun, Lin, Fanhong, Chen, Shutong, Li, Xiaodan, Sun, Hui, Jiang, Guanmin, Fang, Hua, Qin, Jingbo, Fang, Meijuan
Format:	Artículo científico
Language:	en
Published:	Bioorganic chemistry 2025
Subjects:	Humans Cyclin-Dependent Kinase 9 Histone Deacetylase Inhibitors Antineoplastic Agents Structure-Activity Relationship Drug Design Drug Screening Assays, Antitumor Cell Proliferation Molecular Structure Histone Deacetylases Indoles Dose-Response Relationship, Drug Animals Protein Kinase Inhibitors Mice Apoptosis Cell Line, Tumor Molecular Docking Simulation
Online Access:	Acceder al recurso
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