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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of biological sciences
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40384871/ |
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| _version_ | 1868266201734447106 |
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| author | He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai |
| author_facet | He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai |
| collection | PubMed - marine biology |
| contents | Deciphering Scorpion Toxin-Induced Pain: Molecular Mechanisms and Ion Channel Dynamics. He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai Scorpion Venoms Animals Pain Humans Scorpions Ion Channels Scorpion toxins significantly disrupt the normal function of ion channels, leading to abnormal nerve excitability and severe pain responses. Notably, α-type sodium channel toxins (α-NaTx) and β-type sodium channel toxins (β-NaTx) target sodium channels through distinct mechanisms: α-NaTx prolongs channel opening, while β-NaTx lowers the activation threshold, resulting in persistent nerve overexcitation and heightened pain. This review synthesizes current knowledge on pain-inducing venom peptides isolated from various scorpion species, elucidating the underlying molecular mechanisms involving ion channels. Furthermore, it explores the potential applications of these toxins in scientific research and drug development, highlighting their significance in advancing our understanding of pain mechanisms and facilitating the development of novel analgesic therapies. |
| format | Artículo científico |
| id | pubmed_40384871 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of biological sciences |
| record_format | pubmed |
| spellingShingle | Deciphering Scorpion Toxin-Induced Pain: Molecular Mechanisms and Ion Channel Dynamics. He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai Scorpion Venoms Animals Pain Humans Scorpions Ion Channels Deciphering Scorpion Toxin-Induced Pain: Molecular Mechanisms and Ion Channel Dynamics. He, Dangui Lei, Yining Qin, Haixin Cao, Zhijian Kwok, Hang Fai Scorpion Venoms Animals Pain Humans Scorpions Ion Channels Scorpion toxins significantly disrupt the normal function of ion channels, leading to abnormal nerve excitability and severe pain responses. Notably, α-type sodium channel toxins (α-NaTx) and β-type sodium channel toxins (β-NaTx) target sodium channels through distinct mechanisms: α-NaTx prolongs channel opening, while β-NaTx lowers the activation threshold, resulting in persistent nerve overexcitation and heightened pain. This review synthesizes current knowledge on pain-inducing venom peptides isolated from various scorpion species, elucidating the underlying molecular mechanisms involving ion channels. Furthermore, it explores the potential applications of these toxins in scientific research and drug development, highlighting their significance in advancing our understanding of pain mechanisms and facilitating the development of novel analgesic therapies. |
| title | Deciphering Scorpion Toxin-Induced Pain: Molecular Mechanisms and Ion Channel Dynamics. |
| topic | Scorpion Venoms Animals Pain Humans Scorpions Ion Channels |
| url | https://pubmed.ncbi.nlm.nih.gov/40384871/ |