Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth.
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| Natura: | Artículo científico |
| Lingua: | en |
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PLoS biology
2025
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| _version_ | 1868266201721864193 |
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| author | Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A |
| author_facet | Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A |
| collection | PubMed - marine biology |
| contents | Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth. Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A Stereoisomerism Amino Acids Archaea Cell Membrane Permeability Earth, Planet Ribose Origin of Life Permeability Bacteria Deoxyribose Cell Membrane Phospholipids Early in the evolution of life, a proto-metabolic network was encapsulated within a membrane compartment. The permeability characteristics of the membrane determined several key functions of this network by determining which compounds could enter the compartment and which compounds could not. One key feature of known life is the utilization of right-handed d-ribose and d-deoxyribose sugars and left-handed l-amino acid stereochemical isomers (enantiomers); however, it is not clear why life adopted this specific chirality. Generally, archaea have l-phospholipid membrane chemistries and bacteria and eukaryotes have d-phospholipid membrane chemistries. We previously demonstrated that an l-archaeal and a d-intermediate membrane mimic, bearing a mixture of bacterial and archaeal lipid characteristics (a 'hybrid' membrane), displayed increased permeability for several key compounds compared to bacterial-like membranes. Here, we investigate if these membranes can drive stereochemical selection on pentose sugars, hexose sugars, and amino acids. Using permeability assays of homogenous unilamellar vesicles, we demonstrate that both membranes select for d-ribose and d-deoxyribose sugars while the hybrid membrane uniquely selects for a reduced alphabet of l-amino acids. This repertoire includes alanine, the plausible first l-amino acid utilized. We conclude such compartments could provide stereochemical compound selection matching those used by the core metabolism of life. |
| format | Artículo científico |
| id | pubmed_40392769 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | PLoS biology |
| record_format | pubmed |
| spellingShingle | Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth. Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A Stereoisomerism Amino Acids Archaea Cell Membrane Permeability Earth, Planet Ribose Origin of Life Permeability Bacteria Deoxyribose Cell Membrane Phospholipids Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth. Goode, Olivia Łapińska, Urszula Morimoto, Juliano Glover, Georgina Milner, David S Santoro, Alyson E Pagliara, Stefano Richards, Thomas A Stereoisomerism Amino Acids Archaea Cell Membrane Permeability Earth, Planet Ribose Origin of Life Permeability Bacteria Deoxyribose Cell Membrane Phospholipids Early in the evolution of life, a proto-metabolic network was encapsulated within a membrane compartment. The permeability characteristics of the membrane determined several key functions of this network by determining which compounds could enter the compartment and which compounds could not. One key feature of known life is the utilization of right-handed d-ribose and d-deoxyribose sugars and left-handed l-amino acid stereochemical isomers (enantiomers); however, it is not clear why life adopted this specific chirality. Generally, archaea have l-phospholipid membrane chemistries and bacteria and eukaryotes have d-phospholipid membrane chemistries. We previously demonstrated that an l-archaeal and a d-intermediate membrane mimic, bearing a mixture of bacterial and archaeal lipid characteristics (a 'hybrid' membrane), displayed increased permeability for several key compounds compared to bacterial-like membranes. Here, we investigate if these membranes can drive stereochemical selection on pentose sugars, hexose sugars, and amino acids. Using permeability assays of homogenous unilamellar vesicles, we demonstrate that both membranes select for d-ribose and d-deoxyribose sugars while the hybrid membrane uniquely selects for a reduced alphabet of l-amino acids. This repertoire includes alanine, the plausible first l-amino acid utilized. We conclude such compartments could provide stereochemical compound selection matching those used by the core metabolism of life. |
| title | Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth. |
| topic | Stereoisomerism Amino Acids Archaea Cell Membrane Permeability Earth, Planet Ribose Origin of Life Permeability Bacteria Deoxyribose Cell Membrane Phospholipids |
| url | https://pubmed.ncbi.nlm.nih.gov/40392769/ |