Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam .
Fuente:
PubMed
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Open biology
2025
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1868266201720815616 |
|---|---|
| author | Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M |
| author_facet | Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M |
| collection | PubMed - marine biology |
| contents | Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam . Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M Animals Bivalvia Aging Transcriptome Antarctic Regions Epigenesis, Genetic DNA Methylation Cold Temperature Genomics Adaptation, Physiological Epigenomics Gene Expression Profiling Genome Acclimatization Genomic data are lacking for most Antarctic marine invertebrates, predicating our ability to understand physiological adaptation and specific life-history traits, such as longevity. The environmental stress response of the Antarctic infaunal clam is much diminished in older adult animals compared with younger juvenile individuals. However, the mechanism underlying this reduced capacity is unknown. In this study, we describe and analyse the genome of and use it as a tool to understand transcriptomic responses to shell damage across different age cohorts. Gene expression data were combined with reduced representation enzymic methyl sequencing to identify if methylation was acting as an epigenetic mechanism driving age-dependent transcriptional profiles. Our transcriptomic results demonstrated a clear bipartite molecular response in , associated with a rapid growth phase in juveniles and a stabilization phase in reproductively mature adults. Genes active in the response to damage repair in juvenile animals are silent in adults but can be reactivated after several months following damage stimulus; however, these genes were not methylated. Hence, the trigger for this critical and imprinted change in physiological state is, as yet, unknown. While epigenetics is likely involved in this process, the mechanism is unlikely to be methylation. |
| format | Artículo científico |
| id | pubmed_40393507 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Open biology |
| record_format | pubmed |
| spellingShingle | Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam . Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M Animals Bivalvia Aging Transcriptome Antarctic Regions Epigenesis, Genetic DNA Methylation Cold Temperature Genomics Adaptation, Physiological Epigenomics Gene Expression Profiling Genome Acclimatization Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam . Sleight, Victoria A Clark, Melody S Yap-Chiongco, Meghan K Turner, Frances Kocot, Kevin M Animals Bivalvia Aging Transcriptome Antarctic Regions Epigenesis, Genetic DNA Methylation Cold Temperature Genomics Adaptation, Physiological Epigenomics Gene Expression Profiling Genome Acclimatization Genomic data are lacking for most Antarctic marine invertebrates, predicating our ability to understand physiological adaptation and specific life-history traits, such as longevity. The environmental stress response of the Antarctic infaunal clam is much diminished in older adult animals compared with younger juvenile individuals. However, the mechanism underlying this reduced capacity is unknown. In this study, we describe and analyse the genome of and use it as a tool to understand transcriptomic responses to shell damage across different age cohorts. Gene expression data were combined with reduced representation enzymic methyl sequencing to identify if methylation was acting as an epigenetic mechanism driving age-dependent transcriptional profiles. Our transcriptomic results demonstrated a clear bipartite molecular response in , associated with a rapid growth phase in juveniles and a stabilization phase in reproductively mature adults. Genes active in the response to damage repair in juvenile animals are silent in adults but can be reactivated after several months following damage stimulus; however, these genes were not methylated. Hence, the trigger for this critical and imprinted change in physiological state is, as yet, unknown. While epigenetics is likely involved in this process, the mechanism is unlikely to be methylation. |
| title | Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clam . |
| topic | Animals Bivalvia Aging Transcriptome Antarctic Regions Epigenesis, Genetic DNA Methylation Cold Temperature Genomics Adaptation, Physiological Epigenomics Gene Expression Profiling Genome Acclimatization |
| url | https://pubmed.ncbi.nlm.nih.gov/40393507/ |