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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Chemistry & biodiversity
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40418840/ |
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| _version_ | 1868266198759636992 |
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| author | Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing |
| author_facet | Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing |
| collection | PubMed - marine biology |
| contents | Phyllofolactones V-X, Bishomoscalaranes With Proangiogenic and Hypolipidemic Activities From Sponge Phyllospongia foliascens. Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing Animals Zebrafish Porifera Hypolipidemic Agents Humans Antioxidants Biphenyl Compounds Structure-Activity Relationship Picrates Molecular Structure Dose-Response Relationship, Drug Microbial Sensitivity Tests Chemical investigation of the marine sponge Phyllospongia foliascens led to the identification of three new bishomoscalaranes, phyllofolactones V-X (1-3), alongside three known analogs, phyllofolactones M (4) and O-P (5-6). The structures of these bishomoscalaranes were characterized through comprehensive spectroscopic and spectrometric analyses. The in vivo proangiogenic, hypolipidemic, and anti-heart failure effects, as well as the in vitro antimicrobial, cytotoxic, immunosuppressive, and antioxidant properties of these compounds were assessed. Compounds 3 and 4 displayed significant lipid-lowering effects at a concentration of 10 µM in the zebrafish model. Meanwhile, compounds 2 and 5 demonstrated strong proangiogenic activity in zebrafish at the identical concentration of 10 µM. Compound 4 exhibited radical-scavenging activity against both 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium saltfree radicals, with IC values of 17.27 and 18.90 µM, respectively. |
| format | Artículo científico |
| id | pubmed_40418840 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Phyllofolactones V-X, Bishomoscalaranes With Proangiogenic and Hypolipidemic Activities From Sponge Phyllospongia foliascens. Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing Animals Zebrafish Porifera Hypolipidemic Agents Humans Antioxidants Biphenyl Compounds Structure-Activity Relationship Picrates Molecular Structure Dose-Response Relationship, Drug Microbial Sensitivity Tests Phyllofolactones V-X, Bishomoscalaranes With Proangiogenic and Hypolipidemic Activities From Sponge Phyllospongia foliascens. Hu, Bo Xia, Qing Zhu, Yu-Ping Zhang, Yun Jiao, Bing-Hua Xu, Jun Yu, Hao-Bing Animals Zebrafish Porifera Hypolipidemic Agents Humans Antioxidants Biphenyl Compounds Structure-Activity Relationship Picrates Molecular Structure Dose-Response Relationship, Drug Microbial Sensitivity Tests Chemical investigation of the marine sponge Phyllospongia foliascens led to the identification of three new bishomoscalaranes, phyllofolactones V-X (1-3), alongside three known analogs, phyllofolactones M (4) and O-P (5-6). The structures of these bishomoscalaranes were characterized through comprehensive spectroscopic and spectrometric analyses. The in vivo proangiogenic, hypolipidemic, and anti-heart failure effects, as well as the in vitro antimicrobial, cytotoxic, immunosuppressive, and antioxidant properties of these compounds were assessed. Compounds 3 and 4 displayed significant lipid-lowering effects at a concentration of 10 µM in the zebrafish model. Meanwhile, compounds 2 and 5 demonstrated strong proangiogenic activity in zebrafish at the identical concentration of 10 µM. Compound 4 exhibited radical-scavenging activity against both 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium saltfree radicals, with IC values of 17.27 and 18.90 µM, respectively. |
| title | Phyllofolactones V-X, Bishomoscalaranes With Proangiogenic and Hypolipidemic Activities From Sponge Phyllospongia foliascens. |
| topic | Animals Zebrafish Porifera Hypolipidemic Agents Humans Antioxidants Biphenyl Compounds Structure-Activity Relationship Picrates Molecular Structure Dose-Response Relationship, Drug Microbial Sensitivity Tests |
| url | https://pubmed.ncbi.nlm.nih.gov/40418840/ |