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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40422809/ |
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Table of Contents:
- Bioactivity Assessment and Untargeted Metabolomics of the Mediterranean Sea Pen . Scarpato, Silvia Venturi, Daniel Palma Esposito, Fortunato Mangano, Maria Cristina Sarà, Gianluca Margiotta, Francesco Pagano, Ester Miraglia, Maria Sangiovanni, Enrico Garcia-Gil, Mercedes Di Cesare Mannelli, Lorenzo Ghelardini, Carla Dell'Agli, Mario Izzo, Angelo A Nieri, Paola de Pascale, Donatella Della Sala, Gerardo Animals Anthozoa Metabolomics Humans Anti-Inflammatory Agents Mediterranean Sea Cell Line, Tumor Metabolome Cell Survival Biological Products Octocorals have proven to be a prolific source of bioactive natural products, exhibiting a wide spectrum of pharmacological activities. Among octocorals, Pennatulaceans, commonly known as sea pens, are among the most dominant soft coral species living in benthic communities. Nonetheless, reports on bioactivity and chemical investigations of this genus are scarce. This prompted us to shed light on the pharmacological potential of the extracts of the sea pen , Linneus 1758, and gain an overview of its metabolome. Crude octocoral extracts, obtained with a modified Kupchan extraction protocol, were assessed for their bioactivity potential, revealing the hexanic extract to exert anti-inflammatory effects and interesting protective properties in an in vitro model of sarcopenia and in auditory HEI-OC1 cisplatin-treated cells, while the chloroformic extract was active in reducing A375 melanoma cell viability in a concentration-dependent manner. An untargeted metabolomic analysis unveiled that collects a wide array of glycerophospholipids and phosphosphingolipids belonging to the ceramide phosphoinositol class, which were exclusive or more abundant in the hexanic extract. Their proven anti-inflammatory and cytoprotective effects could demonstrate the activity shown by the hexanic extract. In addition, a group of prostaglandins, eluted mainly in the chloroformic extract, were putatively annotated. Since prostanoids from marine origin have been demonstrated to exert cytotoxic and anti-proliferative properties against various cancer cell lines, the presence of PGs in the chloroform extract could justify its anti-melanoma activity. This is the first report on the presence of glycerophospholipids, phosphosphingolipids, and prostaglandins, along with the identification of novel congeners, in sea pens.