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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40427649/ |
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| _version_ | 1868266198739714048 |
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| author | Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang |
| author_facet | Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang |
| collection | PubMed - marine biology |
| contents | Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard . Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang The plateau environments are always harsh, with low pressure, low oxygen, and low temperature, which are detrimental to the survival of organisms. The Qinghai toad-headed lizard has a wide range of altitude adaptation from 2000 to 4600 m. But it is still unclear how organisms maintain tissue function by balancing energy supply and demand changes in high-altitude environments of . We investigated the plateau metabolic adaptation through transcriptome and metabolome analyses of from three populations at different altitudes of the Qinghai-Tibet Plateau. The genes related to carbohydrate metabolism were significantly down-regulated at the high altitude. The metabolites alpha-D-glucose 1-phosphate, beta-D-fructose 6-phosphate, D-glycerate 1,3-diphosphate, 3-phosphoglycerate, and phosphoenolpyruvate in glycolysis/gluconeogenesis were down-regulated, too. The lipid metabolic and fatty acid synthase-related genes were up-regulated at a high altitude. In conclusion, the glycogen utilization-related genes and metabolites experienced broad down-regulation, while lipid-related genes and metabolites had a clear trend of up-regulation. Thus, we suggest that tends to increase lipid utilization and reduce the dependence on glycogen consumption to acclimatize to the high-altitude environment. |
| format | Artículo científico |
| id | pubmed_40427649 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard . Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard . Zhong, Jun Chen, Jian Lu, Yu-Hong Huang, Yu-Fei Hong, Ming-Sheng Ji, Xiang The plateau environments are always harsh, with low pressure, low oxygen, and low temperature, which are detrimental to the survival of organisms. The Qinghai toad-headed lizard has a wide range of altitude adaptation from 2000 to 4600 m. But it is still unclear how organisms maintain tissue function by balancing energy supply and demand changes in high-altitude environments of . We investigated the plateau metabolic adaptation through transcriptome and metabolome analyses of from three populations at different altitudes of the Qinghai-Tibet Plateau. The genes related to carbohydrate metabolism were significantly down-regulated at the high altitude. The metabolites alpha-D-glucose 1-phosphate, beta-D-fructose 6-phosphate, D-glycerate 1,3-diphosphate, 3-phosphoglycerate, and phosphoenolpyruvate in glycolysis/gluconeogenesis were down-regulated, too. The lipid metabolic and fatty acid synthase-related genes were up-regulated at a high altitude. In conclusion, the glycogen utilization-related genes and metabolites experienced broad down-regulation, while lipid-related genes and metabolites had a clear trend of up-regulation. Thus, we suggest that tends to increase lipid utilization and reduce the dependence on glycogen consumption to acclimatize to the high-altitude environment. |
| title | Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard . |
| url | https://pubmed.ncbi.nlm.nih.gov/40427649/ |