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| Format: | Artículo científico |
| Sprache: | en |
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International journal of molecular sciences
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40429670/ |
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| author | Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li |
| author_facet | Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li |
| collection | PubMed - marine biology |
| contents | LncRNA-Mediated Tissue-Specific Plastic Responses to Salinity Changes in Oysters. Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li Animals RNA, Long Noncoding Salinity Hepatopancreas RNA, Messenger Transcriptome Crassostrea Gene Expression Profiling Gene Expression Regulation Organ Specificity Salt Stress Stress, Physiological Salinity is a key environmental factor influencing the survival of aquatic organisms, and transcriptional plasticity is a crucial emergency response to environmental changes. However, most transcriptomic studies on salinity responses have not explored the expression patterns and regulatory mechanisms across different tissues. The Suminoe oyster (), a sessile estuarine species that inhabits fluctuating salinity environments, provides an excellent model for studying the molecular basis of salinity response divergence. All eight tissues responded to acute salinity stresses and exhibited distinct tissue-specific expression patterns in both mRNA and long non-coding RNA (lncRNA) profiles across three salinity conditions. The hepatopancreas and striated muscle were identified as tissues specifically sensitive to hyper- and hypo-saline stress, respectively, based on the number, expression pattern, and plasticity of differentially expressed genes (DEGs). We established lncRNA-mRNA regulatory relationships that environmentally responsive lncRNAs enhanced DEGs' expression and underpinning tissue-specific responses. Under moderate stress, the hepatopancreas and striated muscle initiated positive responses related to water transport and shell closure, respectively. Under severe stress, the hepatopancreas activated cellular resistance pathways, while the striated muscle experienced significant cell death. Our findings provide insights into lncRNA-mediated, tissue-specific environmental responses and lay the foundation for further research into the adaptive evolution of tissue-specific regulation. |
| format | Artículo científico |
| id | pubmed_40429670 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | LncRNA-Mediated Tissue-Specific Plastic Responses to Salinity Changes in Oysters. Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li Animals RNA, Long Noncoding Salinity Hepatopancreas RNA, Messenger Transcriptome Crassostrea Gene Expression Profiling Gene Expression Regulation Organ Specificity Salt Stress Stress, Physiological LncRNA-Mediated Tissue-Specific Plastic Responses to Salinity Changes in Oysters. Zhang, Mengshi Zhao, Jinlong Li, Ao Zhao, Mingjie Huo, Meitong Deng, Jinhe Wang, Luping Wang, Wei Zhang, Guofan Li, Li Animals RNA, Long Noncoding Salinity Hepatopancreas RNA, Messenger Transcriptome Crassostrea Gene Expression Profiling Gene Expression Regulation Organ Specificity Salt Stress Stress, Physiological Salinity is a key environmental factor influencing the survival of aquatic organisms, and transcriptional plasticity is a crucial emergency response to environmental changes. However, most transcriptomic studies on salinity responses have not explored the expression patterns and regulatory mechanisms across different tissues. The Suminoe oyster (), a sessile estuarine species that inhabits fluctuating salinity environments, provides an excellent model for studying the molecular basis of salinity response divergence. All eight tissues responded to acute salinity stresses and exhibited distinct tissue-specific expression patterns in both mRNA and long non-coding RNA (lncRNA) profiles across three salinity conditions. The hepatopancreas and striated muscle were identified as tissues specifically sensitive to hyper- and hypo-saline stress, respectively, based on the number, expression pattern, and plasticity of differentially expressed genes (DEGs). We established lncRNA-mRNA regulatory relationships that environmentally responsive lncRNAs enhanced DEGs' expression and underpinning tissue-specific responses. Under moderate stress, the hepatopancreas and striated muscle initiated positive responses related to water transport and shell closure, respectively. Under severe stress, the hepatopancreas activated cellular resistance pathways, while the striated muscle experienced significant cell death. Our findings provide insights into lncRNA-mediated, tissue-specific environmental responses and lay the foundation for further research into the adaptive evolution of tissue-specific regulation. |
| title | LncRNA-Mediated Tissue-Specific Plastic Responses to Salinity Changes in Oysters. |
| topic | Animals RNA, Long Noncoding Salinity Hepatopancreas RNA, Messenger Transcriptome Crassostrea Gene Expression Profiling Gene Expression Regulation Organ Specificity Salt Stress Stress, Physiological |
| url | https://pubmed.ncbi.nlm.nih.gov/40429670/ |