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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
The Journal of biological chemistry
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40441536/ |
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| author | Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun |
| author_facet | Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun |
| collection | PubMed - marine biology |
| contents | Crustacean methyl farnesoate-binding protein is an insect juvenile hormone-binding protein homolog that inhibits molting. Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun Animals Molting Fatty Acids, Unsaturated Insect Proteins Carrier Proteins Penaeidae Juvenile Hormones Hemolymph Amino Acid Sequence Hepatopancreas Arthropod Proteins Methyl farnesoate (MF) serves as an essential regulator of key developmental processes in crustaceans, similar to juvenile hormones (JHs) in insects. However, it is susceptible to degradation in circulation. Despite the detection of proteins binding to MF in crustacean hemolymph for 3 decades, the precise genes encoding these proteins remain unclear. The present study identifies genes in crustaceans containing the juvenile hormone-binding protein (JHBP) domain. Among the 11 JHBPs found in the Pacific white shrimp (Litopenaeus vannamei), XP_027209752.1, which is primarily expressed in the hepatopancreas, emerges as the predominant form. This protein exhibits selective binding to MF rather than to JHs, leading to its designation as a methyl farnesoate-binding protein (MFBP) in crustaceans. Alterations in the amino acid sequence are predicted to induce structural changes that enhance the affinity of MFBP for MF. Endogenous MFBP inhibits molting, consistent with the function of MF. Furthermore, positive regulation of MFBP by MF has been observed in hepatopancreatic primary cells, with similar trends of hepatopancreatic MFBP mRNA and hemolymph MF levels during molting and ovarian development. This study identifies a novel MFBP in crustaceans that, despite being a homolog of insect JHBP, specifically binds MF to regulate molting in penaeid shrimp. These findings may advance our understanding of crustacean endocrine regulation and provide a molecular basis for improving their aquaculture techniques. |
| format | Artículo científico |
| id | pubmed_40441536 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | The Journal of biological chemistry |
| record_format | pubmed |
| spellingShingle | Crustacean methyl farnesoate-binding protein is an insect juvenile hormone-binding protein homolog that inhibits molting. Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun Animals Molting Fatty Acids, Unsaturated Insect Proteins Carrier Proteins Penaeidae Juvenile Hormones Hemolymph Amino Acid Sequence Hepatopancreas Arthropod Proteins Crustacean methyl farnesoate-binding protein is an insect juvenile hormone-binding protein homolog that inhibits molting. Yang, Hao Chen, Ting Zhang, Xin Zhou, Mingyu Zhang, Lvping Yan, Aifen Chen, Weihao Tan, Guiling Liang, Jingxuan Ren, Chunhua Chen, Xiaoli Li, Zhi Ruan, Yao Li, Jiaxi Li, Hongmei Luo, Peng Wang, Yanhong Jiang, Xiao Yin, Jiayue Ma, Bo Zhu, Chunhua Wu, Xugan Zhang, Jiquan Hu, Chaoqun Animals Molting Fatty Acids, Unsaturated Insect Proteins Carrier Proteins Penaeidae Juvenile Hormones Hemolymph Amino Acid Sequence Hepatopancreas Arthropod Proteins Methyl farnesoate (MF) serves as an essential regulator of key developmental processes in crustaceans, similar to juvenile hormones (JHs) in insects. However, it is susceptible to degradation in circulation. Despite the detection of proteins binding to MF in crustacean hemolymph for 3 decades, the precise genes encoding these proteins remain unclear. The present study identifies genes in crustaceans containing the juvenile hormone-binding protein (JHBP) domain. Among the 11 JHBPs found in the Pacific white shrimp (Litopenaeus vannamei), XP_027209752.1, which is primarily expressed in the hepatopancreas, emerges as the predominant form. This protein exhibits selective binding to MF rather than to JHs, leading to its designation as a methyl farnesoate-binding protein (MFBP) in crustaceans. Alterations in the amino acid sequence are predicted to induce structural changes that enhance the affinity of MFBP for MF. Endogenous MFBP inhibits molting, consistent with the function of MF. Furthermore, positive regulation of MFBP by MF has been observed in hepatopancreatic primary cells, with similar trends of hepatopancreatic MFBP mRNA and hemolymph MF levels during molting and ovarian development. This study identifies a novel MFBP in crustaceans that, despite being a homolog of insect JHBP, specifically binds MF to regulate molting in penaeid shrimp. These findings may advance our understanding of crustacean endocrine regulation and provide a molecular basis for improving their aquaculture techniques. |
| title | Crustacean methyl farnesoate-binding protein is an insect juvenile hormone-binding protein homolog that inhibits molting. |
| topic | Animals Molting Fatty Acids, Unsaturated Insect Proteins Carrier Proteins Penaeidae Juvenile Hormones Hemolymph Amino Acid Sequence Hepatopancreas Arthropod Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/40441536/ |