as a comparative model host for light organ symbiosis.
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PubMed
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
bioRxiv : the preprint server for biology
2025
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| author | Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J |
| author_facet | Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J |
| collection | PubMed - marine biology |
| contents | as a comparative model host for light organ symbiosis. Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J Functional studies of host-microbe interactions benefit from natural model systems that enable exploration of molecular mechanisms at the host-microbe interface. Bioluminescent colonize the light organ of the Hawaiian bobtail squid, , and this binary model has enabled advances in understanding host-microbe communication, colonization specificity, biofilms, intraspecific competition, and quorum sensing. The hummingbird bobtail squid, can be generationally bred and maintained in lab settings and has had multiple genes deleted by CRISPR approaches. The prospect of expanding the utility of the light organ model system by producing multigenerational host lines led us to determine the extent to which the light organ symbiosis parallels known processes in . However, the nature of the light organ, including its microbial constituency and specificity for microbial partners, have not been examined. In this report, we isolate bacteria from animals and tank water. Assays of bacterial behaviors required in the host, as well as host responses to bacterial colonization, illustrate largely parallel phenotypes in and hatchlings. This study reveals to be a valuable comparative model to complement studies in . |
| format | Artículo científico |
| id | pubmed_40462927 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | bioRxiv : the preprint server for biology |
| record_format | pubmed |
| spellingShingle | as a comparative model host for light organ symbiosis. Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J as a comparative model host for light organ symbiosis. Imes, Avery M Pavelsky, Morgan N Badal, Klodia Kamp, Derrick L Briseño, John L Sakmar, Taylor Vogt, Miranda A Nyholm, Spencer V Heath-Heckman, Elizabeth A C Grasse, Bret Septer, Alecia N Mandel, Mark J Functional studies of host-microbe interactions benefit from natural model systems that enable exploration of molecular mechanisms at the host-microbe interface. Bioluminescent colonize the light organ of the Hawaiian bobtail squid, , and this binary model has enabled advances in understanding host-microbe communication, colonization specificity, biofilms, intraspecific competition, and quorum sensing. The hummingbird bobtail squid, can be generationally bred and maintained in lab settings and has had multiple genes deleted by CRISPR approaches. The prospect of expanding the utility of the light organ model system by producing multigenerational host lines led us to determine the extent to which the light organ symbiosis parallels known processes in . However, the nature of the light organ, including its microbial constituency and specificity for microbial partners, have not been examined. In this report, we isolate bacteria from animals and tank water. Assays of bacterial behaviors required in the host, as well as host responses to bacterial colonization, illustrate largely parallel phenotypes in and hatchlings. This study reveals to be a valuable comparative model to complement studies in . |
| title | as a comparative model host for light organ symbiosis. |
| url | https://pubmed.ncbi.nlm.nih.gov/40462927/ |