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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Current biology : CB
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40472853/ |
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| _version_ | 1868266193708646400 |
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| author | Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka |
| author_facet | Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka |
| collection | PubMed - marine biology |
| contents | Oxytocin facilitates human touch-induced play behavior in rats. Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka Animals Oxytocin Rats Male Humans Touch Receptors, Oxytocin Play and Playthings Rats, Sprague-Dawley Social Behavior Touch Perception Supraoptic Nucleus Pleasant touch sensations play a fundamental role in social bonding, yet the neural mechanisms underlying affinity-like behaviors remain poorly understood. Here, we demonstrate that juvenile-adolescent rats, which naturally engage in social play with peers characterized by rough-and-tumble interactions and 50 kHz ultrasonic vocalizations indicating pleasant sensations, develop a strong affinity for human hands through similar playful contact achieved by repeated tickling with human hands. Using this rat with tickling-induced high affinity for human hands, we discovered that repeated tickling mimicking rough-and-tumble play led to increased oxytocin receptor (OTR) expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl). Inhibition of oxytocin signaling in the VMHvl reduced affinity-like behaviors from rats to human hands. These findings suggest that OTR neurons in VMHvl play an important role in the increase in affinity for human hands induced by pleasant touch sensation with human touch-induced play behavior. Based on retrograde and anterograde tracing studies examining the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) as primary sources of oxytocin, we demonstrate that a subset of oxytocin fibers in the VMHvl originate from the SON, suggesting that affinity-like behavior from rats to human hands may be controlled by oxytocin signaling from magnocellular neurons. Together, this work advances our understanding of how oxytocin shapes social behavior and may inform the development of therapeutic strategies to promote positive social interactions. |
| format | Artículo científico |
| id | pubmed_40472853 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Current biology : CB |
| record_format | pubmed |
| spellingShingle | Oxytocin facilitates human touch-induced play behavior in rats. Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka Animals Oxytocin Rats Male Humans Touch Receptors, Oxytocin Play and Playthings Rats, Sprague-Dawley Social Behavior Touch Perception Supraoptic Nucleus Oxytocin facilitates human touch-induced play behavior in rats. Hayashi, Himeka Tateishi, Sayaka Inutsuka, Ayumu Maejima, Sho Hagiwara, Daisuke Sakuma, Yasuo Onaka, Tatsushi Grinevich, Valery Sakamoto, Hirotaka Animals Oxytocin Rats Male Humans Touch Receptors, Oxytocin Play and Playthings Rats, Sprague-Dawley Social Behavior Touch Perception Supraoptic Nucleus Pleasant touch sensations play a fundamental role in social bonding, yet the neural mechanisms underlying affinity-like behaviors remain poorly understood. Here, we demonstrate that juvenile-adolescent rats, which naturally engage in social play with peers characterized by rough-and-tumble interactions and 50 kHz ultrasonic vocalizations indicating pleasant sensations, develop a strong affinity for human hands through similar playful contact achieved by repeated tickling with human hands. Using this rat with tickling-induced high affinity for human hands, we discovered that repeated tickling mimicking rough-and-tumble play led to increased oxytocin receptor (OTR) expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl). Inhibition of oxytocin signaling in the VMHvl reduced affinity-like behaviors from rats to human hands. These findings suggest that OTR neurons in VMHvl play an important role in the increase in affinity for human hands induced by pleasant touch sensation with human touch-induced play behavior. Based on retrograde and anterograde tracing studies examining the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) as primary sources of oxytocin, we demonstrate that a subset of oxytocin fibers in the VMHvl originate from the SON, suggesting that affinity-like behavior from rats to human hands may be controlled by oxytocin signaling from magnocellular neurons. Together, this work advances our understanding of how oxytocin shapes social behavior and may inform the development of therapeutic strategies to promote positive social interactions. |
| title | Oxytocin facilitates human touch-induced play behavior in rats. |
| topic | Animals Oxytocin Rats Male Humans Touch Receptors, Oxytocin Play and Playthings Rats, Sprague-Dawley Social Behavior Touch Perception Supraoptic Nucleus |
| url | https://pubmed.ncbi.nlm.nih.gov/40472853/ |