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| Hauptverfasser: | , , , , , , , |
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| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Journal of natural products
2025
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| Schlagworte: | |
| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40474509/ |
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Inhaltsangabe:
- Cytochalasins from the Sponge-Derived Fungus and Their Biological Activities. Li, Kai Zhang, Yue Jin, Tianyun Li, Lei Yang, Junjie Wang, Sen Wang, Cili Li, Pinglin Animals Aspergillus Zebrafish Porifera Molecular Structure Cytochalasins Humans Apoptosis Anti-Inflammatory Agents NF-kappa B Crystallography, X-Ray Guided by biosynthetic gene cluster analysis, fractionation of the fermentation extract of from the sponge sp. led to the isolation of nine new cytochalasins, named colachalasins A-I (-), along with four known cytochalasins (-). The structures of - were elucidated using spectroscopic data and single-crystal X-ray diffraction. Structurally, compound is characterized by an open 12-carbon chain unprecedented among the cytochalasins. Compounds - demonstrated moderate protective effects against alcohol-induced hepatic damage in zebrafish assays. Compound exhibited potent anti-inflammatory activity by inhibiting the expression of IKKβ, STAT3, TNF-α, IL-1β, NF-κB, NLRP3, IL-6, and MyD88 while enhancing the expression of IL-4 and Nrf2 in zebrafish assays. Additionally, compound showed significant cytotoxicity against NCI-H446 cell lines, with an IC value of 0.67 μM, and induced apoptosis in a dose-dependent manner.