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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
bioRxiv : the preprint server for biology
2025
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40475539/ |
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| _version_ | 1868266193703403521 |
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| author | Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet |
| author_facet | Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet |
| collection | PubMed - marine biology |
| contents | Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity. Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet Applicable methods of rejuvenating organisms and improving resistance to environmental stimuli are needed. During attempts to synchronize heart rates in unhealthy colonial chordates, we observed morphological rejuvenation. While the importance of endogenously generated bioelectric currents in development is well-established and exogenously applied current has shown promise in regenerative medicine, a model that robustly increases longevity and fertility while providing detailed mechanistic insights has not been reported. Here, we report the establishment of such a model using pulsatile electrical current (PEC) in , an established colonial chordate model. PEC treatment significantly improved survival, morphological integrity, stem cell mediated regeneration, and gonad production in . Transcriptomic analysis revealed pathway changes associated with cellular metabolism, cell cycle, stem cell activity, DNA repair, and immune modulation. Notably, PEC-induced expression patterns resemble the exercise-induced macrophage-associated transcriptional response previously observed across several mammalian species. This transcriptomic signature correlated with an increase in immune-cell-containing populations. These findings demonstrate that PEC can improve longevity, vitality, and reproduction in an established model renowned for defining broadly applicable biological principles. These studies offer insights into novel strategies for promoting healthy aging and organismal survival. |
| format | Artículo científico |
| id | pubmed_40475539 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | bioRxiv : the preprint server for biology |
| record_format | pubmed |
| spellingShingle | Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity. Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity. Domen, Jos Voskoboynik, Yotam Levy, Tom Domen, Erica M Ishizuka, Katherine J Palmeri, Karla J Anselmi, Chiara Rolander, Thomas Neff, Norma F Detweiler, Angela M Weissman, Irving L Gandy, Kimberly L Sahoo, Debashis Voskoboynik, Ayelet Applicable methods of rejuvenating organisms and improving resistance to environmental stimuli are needed. During attempts to synchronize heart rates in unhealthy colonial chordates, we observed morphological rejuvenation. While the importance of endogenously generated bioelectric currents in development is well-established and exogenously applied current has shown promise in regenerative medicine, a model that robustly increases longevity and fertility while providing detailed mechanistic insights has not been reported. Here, we report the establishment of such a model using pulsatile electrical current (PEC) in , an established colonial chordate model. PEC treatment significantly improved survival, morphological integrity, stem cell mediated regeneration, and gonad production in . Transcriptomic analysis revealed pathway changes associated with cellular metabolism, cell cycle, stem cell activity, DNA repair, and immune modulation. Notably, PEC-induced expression patterns resemble the exercise-induced macrophage-associated transcriptional response previously observed across several mammalian species. This transcriptomic signature correlated with an increase in immune-cell-containing populations. These findings demonstrate that PEC can improve longevity, vitality, and reproduction in an established model renowned for defining broadly applicable biological principles. These studies offer insights into novel strategies for promoting healthy aging and organismal survival. |
| title | Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity. |
| url | https://pubmed.ncbi.nlm.nih.gov/40475539/ |