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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine pollution bulletin
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40480089/ |
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| _version_ | 1868266193698160640 |
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| author | Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario |
| author_facet | Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario |
| collection | PubMed - marine biology |
| contents | Bioaccumulation and stress markers in fish from an impacted area: Effects of mercury in the marine food system. Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario Animals Water Pollutants, Chemical Fishes Biomarkers Mercury Environmental Monitoring Oxidative Stress Bioaccumulation In this study, wild benthic and demersal fish species (Diplodus annularis, Pagellus erythrinus and Mullus barbatus) from the highly contaminated area of Augusta Bay and from control near sites (Marzamemi and Capo Passero) were selected, to investigate Hg bioaccumulation and its effects on stress, welfare, metabolism and quality. Specifically, biomarkers involved in stress response, oxidative adaptation (Nrf2, Hif-1α and Hsp70), cell cycle regulation (p53 and mTOR), central metabolism (Fas and Glut-4) and inflammatory responses (nuclear factor-κB (NF-κB)) were analyzed. Total lipid content, fatty acid profile and malondialdehyde (MDA) levels were also investigated in muscle and liver tissue to assess oxidative stress and its impact on molecular responses. Hg levels were significantly higher in fish from the impacted area compared to control group as were the levels of biomolecular markers related to different stress responses. In particular, the changes in the levels of proteins involved in the antioxidant defence system, cell cycle progression and lipid composition, suggest the induction of oxidative stress in the liver. Indeed, lipid content and polyunsaturated fatty acids (PUFAs), resulted significantly reduced in fish from the impact with respect to the control sites (p |
| format | Artículo científico |
| id | pubmed_40480089 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine pollution bulletin |
| record_format | pubmed |
| spellingShingle | Bioaccumulation and stress markers in fish from an impacted area: Effects of mercury in the marine food system. Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario Animals Water Pollutants, Chemical Fishes Biomarkers Mercury Environmental Monitoring Oxidative Stress Bioaccumulation Bioaccumulation and stress markers in fish from an impacted area: Effects of mercury in the marine food system. Manuguerra, Simona Giuga, Marta Bonsignore, Maria Arena, Rosaria Traina, Anna Bellante, Antonio Santulli, Andrea Messina, Concetta Maria Sprovieri, Mario Animals Water Pollutants, Chemical Fishes Biomarkers Mercury Environmental Monitoring Oxidative Stress Bioaccumulation In this study, wild benthic and demersal fish species (Diplodus annularis, Pagellus erythrinus and Mullus barbatus) from the highly contaminated area of Augusta Bay and from control near sites (Marzamemi and Capo Passero) were selected, to investigate Hg bioaccumulation and its effects on stress, welfare, metabolism and quality. Specifically, biomarkers involved in stress response, oxidative adaptation (Nrf2, Hif-1α and Hsp70), cell cycle regulation (p53 and mTOR), central metabolism (Fas and Glut-4) and inflammatory responses (nuclear factor-κB (NF-κB)) were analyzed. Total lipid content, fatty acid profile and malondialdehyde (MDA) levels were also investigated in muscle and liver tissue to assess oxidative stress and its impact on molecular responses. Hg levels were significantly higher in fish from the impacted area compared to control group as were the levels of biomolecular markers related to different stress responses. In particular, the changes in the levels of proteins involved in the antioxidant defence system, cell cycle progression and lipid composition, suggest the induction of oxidative stress in the liver. Indeed, lipid content and polyunsaturated fatty acids (PUFAs), resulted significantly reduced in fish from the impact with respect to the control sites (p |
| title | Bioaccumulation and stress markers in fish from an impacted area: Effects of mercury in the marine food system. |
| topic | Animals Water Pollutants, Chemical Fishes Biomarkers Mercury Environmental Monitoring Oxidative Stress Bioaccumulation |
| url | https://pubmed.ncbi.nlm.nih.gov/40480089/ |