Buchumschlag

Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer.

Fuente: PubMed

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Xu, Chenmeng, Wang, Rui, Li, Jia, Li, Xiaomin, Huang, Jianjun, Li, Deshang, Wang, Qianqian, Ma, Weijun, Dehaen, Wim, Chau, Ho-Fai, Fang, Yuyu, Huai, Qiyong
Format:	Artículo científico
Sprache:	en
Veröffentlicht:	Bioorganic & medicinal chemistry 2025
Schlagworte:	Humans Mitochondria Colorectal Neoplasms Cell Proliferation Camptothecin Apoptosis Structure-Activity Relationship Drug Screening Assays, Antitumor Antineoplastic Agents Molecular Structure HCT116 Cells Dose-Response Relationship, Drug
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer.
von: Xu, Chenmeng, et al.
Veröffentlicht: (2026)

Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity.
von: Liu, Xiao-Mei, et al.
Veröffentlicht: (2026)

Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi.
von: Luu, Phuong Vu, et al.
Veröffentlicht: (2026)

Ircindrimanes A-I, nine undescribed meroterpenoids with cytotoxic activities from the marine sponge Ircinia sp.
von: Zhang, Wenjie, et al.
Veröffentlicht: (2025)

Cytotoxicity, apoptosis, molecular docking, and molecular dynamics study of novel compounds of Sulfamide derivatives coupled with DHP scaffolds as potent inhibitors of the MCF-7, A549, SKOV-3, and EA. yh926 carcinoma cells.
von: Abdulrasool, Amjed, et al.
Veröffentlicht: (2026)

Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining.
von: Jayaraman, Vennila, et al.
Veröffentlicht: (2025)

Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52.
von: Xia, Meng-de, et al.
Veröffentlicht: (2025)

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.
von: Xu, Fuju, et al.
Veröffentlicht: (2025)

Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer.
von: Chen, Xiangliu, et al.
Veröffentlicht: (2026)

Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp.
von: Xu, Quan, et al.
Veröffentlicht: (2025)

Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
von: Yu, Jing, et al.
Veröffentlicht: (2026)

Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy.
von: Wang, Lijun, et al.
Veröffentlicht: (2026)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
von: Chen, Xiaohui, et al.
Veröffentlicht: (2025)

Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.
von: Tao, Xiaoyu, et al.
Veröffentlicht: (2025)

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
von: Cao, Yin, et al.
Veröffentlicht: (2025)

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
von: Fang, Zhangyun, et al.
Veröffentlicht: (2026)

Integrating experimental findings and machine learning models to predict the anticancer potential of newly synthesized oversulfated fucoidan.
von: Kocabay, Samet, et al.
Veröffentlicht: (2026)

Suaeglaucin C: a new coumaronochromone isolated from .
von: Jia, Jia, et al.
Veröffentlicht: (2026)

Biogenic gold nanoparticles synthesized from Caulerpa sertularioides: A green approach for antioxidant, antibacterial and anticancer applications.
von: Sivakumar, Vibitha Sri, et al.
Veröffentlicht: (2025)

Antibacterial and Cytotoxic Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512.
von: Ban, Zi-Wei, et al.
Veröffentlicht: (2026)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
von: Du, Lin, et al.
Veröffentlicht: (2025)

Total syntheses of Kavaratamide A and 5--Kavaratamide A.
von: Ren, Tieshun, et al.
Veröffentlicht: (2025)

Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium sp.
von: Niiyama, Mizuho, et al.
Veröffentlicht: (2026)

Metabolic Blockade-Based Genome Mining of SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.
von: Li, Kunlong, et al.
Veröffentlicht: (2025)

Prediction of newly synthesized heparin mimic's effects as heparanase inhibitor in cancer treatments via variational quantum neural networks.
von: Kocabay, Samet, et al.
Veröffentlicht: (2025)

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
von: Mao, Churu, et al.
Veröffentlicht: (2024)

Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.
von: Deng, Guangli, et al.
Veröffentlicht: (2026)

PPTase-Based Activation Unlocks New Anthraquinones from Marine-Derived sp. SCSIO 07396.
von: Li, Xiaohua, et al.
Veröffentlicht: (2026)

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.
von: Zhao, Xiuhe, et al.
Veröffentlicht: (2024)

The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from on Human Colon Cancer HCT116 Cells.
von: Zhang, Yuebin, et al.
Veröffentlicht: (2024)

Undescribed alkaloids, peptides and polyketides from marine sediment-derived fungus Aspergillus terreus PPS1.
von: Zheng, Yao-Yao, et al.
Veröffentlicht: (2025)

Candindoles A and B, Heterozygous Terphenyl-Indole Alkaloids with Antifungal and Cytotoxic Activities from the Marine-Derived Fungus HNNU0546.
von: Liu, Yi-Yi, et al.
Veröffentlicht: (2025)

Tumor Microenvironment-Responsive Multinucleated Nanocomplexes Loaded with Carbon Dots for Combined Photothermal/Chemodynamic Therapy of Breast Cancer.
von: Zhu, Zihan, et al.
Veröffentlicht: (2025)

SMART-assisted discovery of scalaranes from the marine sponge Lendenfeldia sp. and its anti-osteoclastogenesis activity.
von: Pham, Quoc-Vu, et al.
Veröffentlicht: (2026)

Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy.
von: Liang, Anqi, et al.
Veröffentlicht: (2025)

New Phthalide Derivatives With Cardioprotective Effects From the Marine Fungus Diaporthe phaseolorum HZ-2.
von: Feng, Ran-Qi, et al.
Veröffentlicht: (2026)

Exploring Novel Nitrofuryl-1,3,4-Thiadiazole-Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity.
von: Mousavi, Alireza, et al.
Veröffentlicht: (2026)

Picolinic Acid Derivatives and Biosynthetic Pathway from SDU-F549.
von: Chen, Liuhai, et al.
Veröffentlicht: (2026)

Bioassay-Guided Procedure Coupled with HR-ESIMS Dereplication for Isolation of Antiproliferative Bromo-Tyramine Derivative from .
von: Esposito, Germana, et al.
Veröffentlicht: (2025)

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
von: Qiao, Ziwen, et al.
Veröffentlicht: (2025)