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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40490901/ |
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| _version_ | 1868266193681383427 |
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| author | Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung |
| author_facet | Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung |
| collection | PubMed - marine biology |
| contents | Zoanthamine-Type Alkaloids Derived from Cultured with Therapeutic Potential Against Osteoporosis. Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung Alkaloids Osteoporosis Humans Molecular Structure Extracts of the zoanthid from (ZK) exhibited significant antiosteoporotic activity in MG-63 cells, prompting the use of Global Natural Products Social Molecular Networking (GNPS) to identify alkaloid-rich fractions. Subsequently, five new zoanthamine-type alkaloids, norzoabenzaldehyde (), norzoazepanol (), 3-acetoxynorzoanthaminone (), 11-hydroxynorzoanthamide B (), and 11-hydroxyzoanthamide B (), were isolated. Structural elucidation was achieved by spectroscopic analyses, time-dependent density functional theory nuclear magnetic resonance (TDDFT-NMR) calculations, and electronic circular dichroism (ECD). The alkaloid 3-hydroxynorzoanthamine exhibited notable alkaline phosphatase activity and promoted mineralization, with an IC value of 20 μM, underscoring its potential as a promising lead compound for the development of osteoporosis therapeutics. |
| format | Artículo científico |
| id | pubmed_40490901 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of natural products |
| record_format | pubmed |
| spellingShingle | Zoanthamine-Type Alkaloids Derived from Cultured with Therapeutic Potential Against Osteoporosis. Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung Alkaloids Osteoporosis Humans Molecular Structure Zoanthamine-Type Alkaloids Derived from Cultured with Therapeutic Potential Against Osteoporosis. Pham, Ngoc-Thac Peng, Bo-Rong Le, Huong-Giang Cheng, You-Song Chen, Yun-Shiuan Huynh, Thanh Hao Chen, Lo-Yun Nguyen, Le Anh Tuan Nguyen, Dang T Chang, Yu-Chia Su, Jui-Hsin El-Shazly, Mohamed Lee, Mei-Hsien Lai, Kuei-Hung Alkaloids Osteoporosis Humans Molecular Structure Extracts of the zoanthid from (ZK) exhibited significant antiosteoporotic activity in MG-63 cells, prompting the use of Global Natural Products Social Molecular Networking (GNPS) to identify alkaloid-rich fractions. Subsequently, five new zoanthamine-type alkaloids, norzoabenzaldehyde (), norzoazepanol (), 3-acetoxynorzoanthaminone (), 11-hydroxynorzoanthamide B (), and 11-hydroxyzoanthamide B (), were isolated. Structural elucidation was achieved by spectroscopic analyses, time-dependent density functional theory nuclear magnetic resonance (TDDFT-NMR) calculations, and electronic circular dichroism (ECD). The alkaloid 3-hydroxynorzoanthamine exhibited notable alkaline phosphatase activity and promoted mineralization, with an IC value of 20 μM, underscoring its potential as a promising lead compound for the development of osteoporosis therapeutics. |
| title | Zoanthamine-Type Alkaloids Derived from Cultured with Therapeutic Potential Against Osteoporosis. |
| topic | Alkaloids Osteoporosis Humans Molecular Structure |
| url | https://pubmed.ncbi.nlm.nih.gov/40490901/ |