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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of hazardous materials
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40513160/ |
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| _version_ | 1868266191340961792 |
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| author | Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao |
| author_facet | Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao |
| collection | PubMed - marine biology |
| contents | Deciphering the intricate microbial responses and potential degraders of p-chloro-m-xylenol in marine sediments. Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao Geologic Sediments Xylenes Water Pollutants, Chemical Biodegradation, Environmental Bacteria The widespread use of p-chloro-m-xylenol (PCMX) as a broad-spectrum antimicrobial agent raises concerns about its ecological risks in ecosystems. While prior studies focused on activated sludge systems, the impacts of PCMX on marine systems remain unknown. Here, we systematically investigated the responses of marine sediment communities to PCMX (0.005-50 mg/L) exposure through integrated enzymatic assays, multi-omics, and enrichment culture approaches. High PCMX exposure (50 mg/L) significantly suppressed dehydrogenase (63.8 %) and protease (53.8 %) activity, reduced microbial diversity, and inhibited nutrient cycling and ATP production. Meanwhile, antibiotic resistance genes associated with efflux pumps were enriched. Metagenomic analysis revealed upregulated aromatic degradation pathways and stress-response mechanisms (e.g., chemotaxis and biofilm formation) under PCMX stress. A halotolerant marine consortium enriched from high-PCMX sediments demonstrated efficient PCMX degradation (50 mg/L, 72 h) across broad salinity (1.5-5.5 % NaCl) and temperature (25-40°C) ranges, with metabolite profiling suggesting ortho-cleavage pathways. This work underscores the need for regulatory measures to mitigate the ecological risks posed by PCMX in marine ecosystems, while simultaneously demonstrating the remediation potential of a halotolerant microbial consortium for remediating contaminated environments. |
| format | Artículo científico |
| id | pubmed_40513160 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of hazardous materials |
| record_format | pubmed |
| spellingShingle | Deciphering the intricate microbial responses and potential degraders of p-chloro-m-xylenol in marine sediments. Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao Geologic Sediments Xylenes Water Pollutants, Chemical Biodegradation, Environmental Bacteria Deciphering the intricate microbial responses and potential degraders of p-chloro-m-xylenol in marine sediments. Shi, Jia Zhao, Liang Fan, Minghao Yao, Jingwen Wang, Jingwei Xu, Dan Ma, Qiao Geologic Sediments Xylenes Water Pollutants, Chemical Biodegradation, Environmental Bacteria The widespread use of p-chloro-m-xylenol (PCMX) as a broad-spectrum antimicrobial agent raises concerns about its ecological risks in ecosystems. While prior studies focused on activated sludge systems, the impacts of PCMX on marine systems remain unknown. Here, we systematically investigated the responses of marine sediment communities to PCMX (0.005-50 mg/L) exposure through integrated enzymatic assays, multi-omics, and enrichment culture approaches. High PCMX exposure (50 mg/L) significantly suppressed dehydrogenase (63.8 %) and protease (53.8 %) activity, reduced microbial diversity, and inhibited nutrient cycling and ATP production. Meanwhile, antibiotic resistance genes associated with efflux pumps were enriched. Metagenomic analysis revealed upregulated aromatic degradation pathways and stress-response mechanisms (e.g., chemotaxis and biofilm formation) under PCMX stress. A halotolerant marine consortium enriched from high-PCMX sediments demonstrated efficient PCMX degradation (50 mg/L, 72 h) across broad salinity (1.5-5.5 % NaCl) and temperature (25-40°C) ranges, with metabolite profiling suggesting ortho-cleavage pathways. This work underscores the need for regulatory measures to mitigate the ecological risks posed by PCMX in marine ecosystems, while simultaneously demonstrating the remediation potential of a halotolerant microbial consortium for remediating contaminated environments. |
| title | Deciphering the intricate microbial responses and potential degraders of p-chloro-m-xylenol in marine sediments. |
| topic | Geologic Sediments Xylenes Water Pollutants, Chemical Biodegradation, Environmental Bacteria |
| url | https://pubmed.ncbi.nlm.nih.gov/40513160/ |