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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40523032/ |
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Table of Contents:
- Molecular Networking-Driven Discovery of Antifungal Azaphilone Dimers from the Marine-Derived Fungus sp. HK1-8. Chen, Min Li, Zhong-Hui Zhu, Xia-Hao Shen, Li Chen, Long Wu, Tian-Chi Zhang, Li-Kui Wang, Juan-Juan Wang, Chang-Yun Pigments, Biological Benzopyrans Molecular Structure Antifungal Agents Rhizoctonia Marine Biology Microbial Sensitivity Tests Ascomycota A novel azaphilone dimer, humilone A (), along with its related monomer, humilone B (), was isolated from cultures of the marine-derived fungus sp. HK1-8 using a molecular networking-guided discovery approach. Further investigation of the molecular family of azaphilone dimers led to the putative identification of four analogues, humilones C-F (-), based on systematic analysis of their characteristic MS/MS fragmentation patterns. Detailed fragmentation studies of the dimers revealed that the predominant cleavage fragments originated from C-C bond scission at the dimeric methylene bridge. Compound displayed antifungal activity against .