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| Format: | Artículo científico |
| Sprache: | en |
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Nature ecology & evolution
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40533512/ |
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| author | Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa |
| author_facet | Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa |
| collection | PubMed - marine biology |
| contents | An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa Animals Gene Rearrangement Genome Annelida Evolution, Molecular Phylogeny Synteny Biological Evolution The genomic basis of cladogenesis and adaptive evolutionary change has intrigued biologists for decades. Here we show that the tectonics of genome evolution in clitellates, a clade composed of most freshwater and all terrestrial species of the phylum Annelida, is characterized by extensive genome-wide scrambling that resulted in a massive loss of macrosynteny between marine annelids and clitellates. These massive rearrangements included the formation of putative neocentromeres with newly acquired transposable elements and preceded a further period of genome-wide reshaping events, potentially triggered by the loss of genes involved in genome stability and homoeostasis of cell division. Notably, whereas these rearrangements broke short-range interactions observed between Hox genes in marine annelids, they were reformed as long-range interactions in clitellates. Our findings reveal extensive genomic reshaping in clitellates at both the linear (2D) and three-dimensional (3D) levels, suggesting that unlike in other animal lineages where synteny conservation constrains structural evolution, clitellates exhibit a remarkable tolerance for chromosomal rearrangements. Our study thus suggests that the genomic landscape of Clitellata resulted from a rare burst of genomic changes that ended a long period of stability that persists across large phylogenetic distances. |
| format | Artículo científico |
| id | pubmed_40533512 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Nature ecology & evolution |
| record_format | pubmed |
| spellingShingle | An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa Animals Gene Rearrangement Genome Annelida Evolution, Molecular Phylogeny Synteny Biological Evolution An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. Vargas-Chávez, Carlos Benítez-Álvarez, Lisandra Martínez-Redondo, Gemma I Álvarez-González, Lucía Salces-Ortiz, Judit Eleftheriadi, Klara Escudero, Nuria Guiglielmoni, Nadège Flot, Jean-François Novo, Marta Ruiz-Herrera, Aurora McLysaght, Aoife Fernández, Rosa Animals Gene Rearrangement Genome Annelida Evolution, Molecular Phylogeny Synteny Biological Evolution The genomic basis of cladogenesis and adaptive evolutionary change has intrigued biologists for decades. Here we show that the tectonics of genome evolution in clitellates, a clade composed of most freshwater and all terrestrial species of the phylum Annelida, is characterized by extensive genome-wide scrambling that resulted in a massive loss of macrosynteny between marine annelids and clitellates. These massive rearrangements included the formation of putative neocentromeres with newly acquired transposable elements and preceded a further period of genome-wide reshaping events, potentially triggered by the loss of genes involved in genome stability and homoeostasis of cell division. Notably, whereas these rearrangements broke short-range interactions observed between Hox genes in marine annelids, they were reformed as long-range interactions in clitellates. Our findings reveal extensive genomic reshaping in clitellates at both the linear (2D) and three-dimensional (3D) levels, suggesting that unlike in other animal lineages where synteny conservation constrains structural evolution, clitellates exhibit a remarkable tolerance for chromosomal rearrangements. Our study thus suggests that the genomic landscape of Clitellata resulted from a rare burst of genomic changes that ended a long period of stability that persists across large phylogenetic distances. |
| title | An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. |
| topic | Animals Gene Rearrangement Genome Annelida Evolution, Molecular Phylogeny Synteny Biological Evolution |
| url | https://pubmed.ncbi.nlm.nih.gov/40533512/ |