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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of microbiology and biotechnology
2025
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40537895/ |
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| _version_ | 1868266188992151554 |
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| author | Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo |
| author_facet | Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo |
| collection | PubMed - marine biology |
| contents | Chemical Profiling and Immune-Stimulating Activity of Solvent Fractions Derived from Dietary . Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo Animals Chlorella Mice Solvents Interferon-gamma Tumor Necrosis Factor-alpha T-Lymphocytes Chlorella vulgaris Lipids Dietary Supplements Tandem Mass Spectrometry Adjuvants, Immunologic Plant Extracts Chlorella, a genus of single-celled green algae, is widely industrially cultivated as a dietary supplement ingredient due to its high protein content and various nutrients. In this study, the immune-stimulating effect of solvent fractions prepared from (CV) and (CP) was evaluated through the expression of immune-related factors, such as TNF-α and IFN-γ in T cells obtained from mice. Both species showed immunostimulatory effects in hexane and butanol fractions, but CV increased TNF-α only, while CP elevated both TNF-α and IFN-γ. In addition, the lipid profile of was characterized using non-selective LC-MS/MS-based metabolomic analysis. According to the lipidomic results, the two species differed in lipid composition, with PC 32:1, PC 32:2, PC 34:5, DGDG 34:4, and DGDG 34:5 being enriched in the active fractions of CV, and PC 34:1, PC 34:2, PC O-15:2 and DGTS 34:4 being abundant in the fractions of CP. Furthermore, 5'-methylthioadenosine (MTA), which was detected in both species, also exhibited immunostimulatory properties. |
| format | Artículo científico |
| id | pubmed_40537895 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of microbiology and biotechnology |
| record_format | pubmed |
| spellingShingle | Chemical Profiling and Immune-Stimulating Activity of Solvent Fractions Derived from Dietary . Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo Animals Chlorella Mice Solvents Interferon-gamma Tumor Necrosis Factor-alpha T-Lymphocytes Chlorella vulgaris Lipids Dietary Supplements Tandem Mass Spectrometry Adjuvants, Immunologic Plant Extracts Chemical Profiling and Immune-Stimulating Activity of Solvent Fractions Derived from Dietary . Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo Animals Chlorella Mice Solvents Interferon-gamma Tumor Necrosis Factor-alpha T-Lymphocytes Chlorella vulgaris Lipids Dietary Supplements Tandem Mass Spectrometry Adjuvants, Immunologic Plant Extracts Chlorella, a genus of single-celled green algae, is widely industrially cultivated as a dietary supplement ingredient due to its high protein content and various nutrients. In this study, the immune-stimulating effect of solvent fractions prepared from (CV) and (CP) was evaluated through the expression of immune-related factors, such as TNF-α and IFN-γ in T cells obtained from mice. Both species showed immunostimulatory effects in hexane and butanol fractions, but CV increased TNF-α only, while CP elevated both TNF-α and IFN-γ. In addition, the lipid profile of was characterized using non-selective LC-MS/MS-based metabolomic analysis. According to the lipidomic results, the two species differed in lipid composition, with PC 32:1, PC 32:2, PC 34:5, DGDG 34:4, and DGDG 34:5 being enriched in the active fractions of CV, and PC 34:1, PC 34:2, PC O-15:2 and DGTS 34:4 being abundant in the fractions of CP. Furthermore, 5'-methylthioadenosine (MTA), which was detected in both species, also exhibited immunostimulatory properties. |
| title | Chemical Profiling and Immune-Stimulating Activity of Solvent Fractions Derived from Dietary . |
| topic | Animals Chlorella Mice Solvents Interferon-gamma Tumor Necrosis Factor-alpha T-Lymphocytes Chlorella vulgaris Lipids Dietary Supplements Tandem Mass Spectrometry Adjuvants, Immunologic Plant Extracts |
| url | https://pubmed.ncbi.nlm.nih.gov/40537895/ |