Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Journal of microbiology and biotechnology
2025
|
| Schlagworte: | |
| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40537895/ |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Inhaltsangabe:
- Chemical Profiling and Immune-Stimulating Activity of Solvent Fractions Derived from Dietary . Jo, Seung-Woo Velankanni, Priyanka Cam, Nhung Do Thi Nguyen, Chau Hoang Bao Jeon, Jin-Young Kim, Bo-Ra Lee, Dae-Hee Lee, Choong-Gu Park, Jin-Soo Animals Chlorella Mice Solvents Interferon-gamma Tumor Necrosis Factor-alpha T-Lymphocytes Chlorella vulgaris Lipids Dietary Supplements Tandem Mass Spectrometry Adjuvants, Immunologic Plant Extracts Chlorella, a genus of single-celled green algae, is widely industrially cultivated as a dietary supplement ingredient due to its high protein content and various nutrients. In this study, the immune-stimulating effect of solvent fractions prepared from (CV) and (CP) was evaluated through the expression of immune-related factors, such as TNF-α and IFN-γ in T cells obtained from mice. Both species showed immunostimulatory effects in hexane and butanol fractions, but CV increased TNF-α only, while CP elevated both TNF-α and IFN-γ. In addition, the lipid profile of was characterized using non-selective LC-MS/MS-based metabolomic analysis. According to the lipidomic results, the two species differed in lipid composition, with PC 32:1, PC 32:2, PC 34:5, DGDG 34:4, and DGDG 34:5 being enriched in the active fractions of CV, and PC 34:1, PC 34:2, PC O-15:2 and DGTS 34:4 being abundant in the fractions of CP. Furthermore, 5'-methylthioadenosine (MTA), which was detected in both species, also exhibited immunostimulatory properties.