Salvato in:
| Autori principali: | , , , , , , , , , , , , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Environmental science & technology
2025
|
| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/40539821/ |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
Sommario:
- Dissecting the Role of Natural Toxins and Anthropogenic Contaminants in Mixture Effects of Seawater Chemical Cocktails on Cetacean Skin Fibroblasts. Liu, Xintong Liang, Bo Yao, Siyu Xiong, Anqi Zhang, Xiaohua Sun, Yajing Zhang, Li Li, Changchao Ruan, Yuefei Yan, Meng Ho, Yuen-Wa Fang, James K H Wang, Bei Leusch, Frederic D L Schlenk, Daniel Liu, Wenhua Leung, Kenneth Mei Yee Jin, Ling N Animals Fibroblasts Skin Seawater Reactive Oxygen Species Water Pollutants, Chemical Marine Toxins Porpoises Marine mammal skin, in contact with seawater containing diverse chemicals, reflects species health and environmental quality. The contributions of natural toxins and anthropogenic contaminants to the effects of such chemical mixtures remain poorly quantified. Using skin fibroblast cells from the Indo-Pacific finless porpoise and humpback dolphin, we assessed the toxic potential of seawater extracts, focusing on cytotoxicity and intracellular reactive oxygen species (ROS) formation. Among the 38 studied chemicals prevalent in seawater, four algal toxins were 1-6 orders of magnitude more potent than 30 anthropogenic chemicals, including antibiotics, ultraviolet filters, per- and polyfluoroalkyl substances (PFASs), and polyaromatic hydrocarbons. Pectenotoxin-2 accounted for 92% of the cytotoxicity triggered by the mixture of all studied chemicals, which collectively explained 34% of seawater-induced cytotoxicity in porpoise cells. For ROS induction, although all studied chemicals collectively explained a small fraction (