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| Format: | Artículo científico |
| Sprache: | en |
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Asian Pacific journal of cancer prevention : APJCP
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40542786/ |
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| author | Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany |
| author_facet | Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany |
| collection | PubMed - marine biology |
| contents | Protective Role of Bee Venom (Apis mellifera) Against Kidney Damage in Female Mice with Cancer. Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany Animals Female Mice Bee Venoms Carcinoma, Ehrlich Tumor Kidney Bees Kidney Diseases Protective Agents Urea Creatinine Cancer is a dreadful disease that has a huge, negative impact on people's personal, social, and financial lives, as well as their healthcare. The purpose of our study is to evaluate the capability of Apis mellifera (A.M.), to reduce the renal toxicity and tissue damage caused by the Ehrlich ascites carcinoma (EAC) in mice. A total of forty female Swiss albino mice were divided evenly among four groups (G1, control; G2, A.M.; G3, EAC; and G4, EAC+ A.M.). The current results revealed that EAC caused renal tissue damage, and increase in the serum urea, creatinine, potassium, and chloride ion levels. They also caused a significant decrease in the levels of sodium and calcium ions in the blood, as compared to the normal control. Furthermore, EAC caused a variety of pathological alterations in the glomeruli and renal tubules, including mild glomerular shrinkage, notable cellular infiltration, marked renal injury, and marked renal tissue degradation. When EAC was treated with A.M. (EAC+ A.M.), the kidney structure and function improved, in comparison to the use of EAC alone. The serum urea, creatinine, potassium, and chloride ion levels decreased, but the sodium and calcium ion levels increased. It was possible to conclude that A.M. could shield the kidneys from renal toxicity caused by the EAC cells. |
| format | Artículo científico |
| id | pubmed_40542786 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Asian Pacific journal of cancer prevention : APJCP |
| record_format | pubmed |
| spellingShingle | Protective Role of Bee Venom (Apis mellifera) Against Kidney Damage in Female Mice with Cancer. Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany Animals Female Mice Bee Venoms Carcinoma, Ehrlich Tumor Kidney Bees Kidney Diseases Protective Agents Urea Creatinine Protective Role of Bee Venom (Apis mellifera) Against Kidney Damage in Female Mice with Cancer. Salam Hussein, Mohanad Falah Abass, Shahad Flayyih Hasan, Ahmed G Al-Dulimi, Ali M El-Wahsh, Hany Animals Female Mice Bee Venoms Carcinoma, Ehrlich Tumor Kidney Bees Kidney Diseases Protective Agents Urea Creatinine Cancer is a dreadful disease that has a huge, negative impact on people's personal, social, and financial lives, as well as their healthcare. The purpose of our study is to evaluate the capability of Apis mellifera (A.M.), to reduce the renal toxicity and tissue damage caused by the Ehrlich ascites carcinoma (EAC) in mice. A total of forty female Swiss albino mice were divided evenly among four groups (G1, control; G2, A.M.; G3, EAC; and G4, EAC+ A.M.). The current results revealed that EAC caused renal tissue damage, and increase in the serum urea, creatinine, potassium, and chloride ion levels. They also caused a significant decrease in the levels of sodium and calcium ions in the blood, as compared to the normal control. Furthermore, EAC caused a variety of pathological alterations in the glomeruli and renal tubules, including mild glomerular shrinkage, notable cellular infiltration, marked renal injury, and marked renal tissue degradation. When EAC was treated with A.M. (EAC+ A.M.), the kidney structure and function improved, in comparison to the use of EAC alone. The serum urea, creatinine, potassium, and chloride ion levels decreased, but the sodium and calcium ion levels increased. It was possible to conclude that A.M. could shield the kidneys from renal toxicity caused by the EAC cells. |
| title | Protective Role of Bee Venom (Apis mellifera) Against Kidney Damage in Female Mice with Cancer. |
| topic | Animals Female Mice Bee Venoms Carcinoma, Ehrlich Tumor Kidney Bees Kidney Diseases Protective Agents Urea Creatinine |
| url | https://pubmed.ncbi.nlm.nih.gov/40542786/ |