Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40559644/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266186740858882 |
|---|---|
| author | Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco |
| author_facet | Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco |
| collection | PubMed - marine biology |
| contents | Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology. Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco Xanthophylls Humans Animals Anti-Inflammatory Agents Oxidative Stress Antioxidants Stem Cells Microalgae Aquatic Organisms Inflammation Astaxanthin (ASX) is a xanthophyll carotenoid mainly derived from marine microalgae such as and , as well as the yeast . Its chemical nature structure, rich in conjugated double bonds, carbonyl, and hydroxyl groups, confers potent antioxidant and anti-inflammatory properties. ASX modulates oxidative stress via the PI3K/Akt-Nrf2 pathway and suppresses NF-κB-mediated inflammatory responses, reducing cytokine levels such as TNF-α, IL-6, and iNOS. ASX exerts dual apoptotic effects, cytoprotective in non-transformed cells and pro-apoptotic in cancer cells through p53 activation. Sustainable extraction techniques, especially supercritical CO, have improved its industrial applicability. Recent findings highlight ASX's role in stem cell biology, enhancing proliferation, supporting lineage-specific differentiation, and protecting against oxidative and inflammatory damage, which is a crucial issue for regenerative medicine applications. These multifaceted molecular effects support ASX's therapeutic potential in chronic diseases, including diabetes, cardiovascular pathologies, and cancer. This review outlines ASX's natural sources, extraction methods, and biological mechanisms, emphasizing its application in oxidative stress- and inflammation-related conditions. |
| format | Artículo científico |
| id | pubmed_40559644 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology. Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco Xanthophylls Humans Animals Anti-Inflammatory Agents Oxidative Stress Antioxidants Stem Cells Microalgae Aquatic Organisms Inflammation Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology. Rambaldi, Aretha Paris, Francesca Marrazzo, Pasquale Costa, Roberta Ratti, Stefano Alviano, Francesco Xanthophylls Humans Animals Anti-Inflammatory Agents Oxidative Stress Antioxidants Stem Cells Microalgae Aquatic Organisms Inflammation Astaxanthin (ASX) is a xanthophyll carotenoid mainly derived from marine microalgae such as and , as well as the yeast . Its chemical nature structure, rich in conjugated double bonds, carbonyl, and hydroxyl groups, confers potent antioxidant and anti-inflammatory properties. ASX modulates oxidative stress via the PI3K/Akt-Nrf2 pathway and suppresses NF-κB-mediated inflammatory responses, reducing cytokine levels such as TNF-α, IL-6, and iNOS. ASX exerts dual apoptotic effects, cytoprotective in non-transformed cells and pro-apoptotic in cancer cells through p53 activation. Sustainable extraction techniques, especially supercritical CO, have improved its industrial applicability. Recent findings highlight ASX's role in stem cell biology, enhancing proliferation, supporting lineage-specific differentiation, and protecting against oxidative and inflammatory damage, which is a crucial issue for regenerative medicine applications. These multifaceted molecular effects support ASX's therapeutic potential in chronic diseases, including diabetes, cardiovascular pathologies, and cancer. This review outlines ASX's natural sources, extraction methods, and biological mechanisms, emphasizing its application in oxidative stress- and inflammation-related conditions. |
| title | Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology. |
| topic | Xanthophylls Humans Animals Anti-Inflammatory Agents Oxidative Stress Antioxidants Stem Cells Microalgae Aquatic Organisms Inflammation |
| url | https://pubmed.ncbi.nlm.nih.gov/40559644/ |