Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons.
Fuente:
PubMed
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Science advances
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1868266186734567424 |
|---|---|
| author | Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi |
| author_facet | Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi |
| collection | PubMed - marine biology |
| contents | Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons. Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi Animals Hematopoietic Stem Cells Stem Cell Niche Invertebrates Bone Marrow Hematopoiesis Cell Lineage Hemocytes Biological Evolution Skeletal harboring of hematopoietic stem cells (HSCs) is generally considered as vertebrate-specific innovation during water-to-land transition. However, this long-standing view has not been rigorously evaluated as hematopoietic sites remain poorly understood in most invertebrate groups. We report, to our knowledge, the first discovery of abundant HSCs in adult mollusk shells, an invertebrate hematopoietic niche resembling vertebrate bone marrow (BM). Cell-lineage analysis and functional assays reveal the developmental origin of HSCs during larval shell formation and their participation in hemocyte-mediated shell regeneration and soft-body blood supply. Widespread skeleton-related HSC-like cells are found in diverse invertebrate groups and bony fish group, suggesting skeletons as a universal niche for animal HSCs and HSC-skeleton association preceding vertebrate water-to-land transition. Comparison of invertebrate and vertebrate skeletal HSCs enables the macroevolutionary profiling of a core-set of animal HSC regulators. Our findings would boost fundamental paradigm shifts for hematopoiesis and stem cell research in invertebrates and provide the redefined understanding of vertebrate BM evolution and water-to-land transition. |
| format | Artículo científico |
| id | pubmed_40561015 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Science advances |
| record_format | pubmed |
| spellingShingle | Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons. Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi Animals Hematopoietic Stem Cells Stem Cell Niche Invertebrates Bone Marrow Hematopoiesis Cell Lineage Hemocytes Biological Evolution Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons. Lian, Shanshan Hu, Naina Chen, Xiaomei Dai, Xiaoting Zhu, Xuan Qiao, Runyu Liu, Sinuo Lu, Yuan Zhang, Fengmei Sun, Fengzhi Pu, Zhongqi Yang, Zujing Xu, Runjia Wang, Hao Zhao, Liang Xing, Qiang Li, Shoujie Wang, Wei Dong, Bo Zhang, Lingling Hu, Jingjie Wang, Jing Bao, Zhenmin Wang, Shi Animals Hematopoietic Stem Cells Stem Cell Niche Invertebrates Bone Marrow Hematopoiesis Cell Lineage Hemocytes Biological Evolution Skeletal harboring of hematopoietic stem cells (HSCs) is generally considered as vertebrate-specific innovation during water-to-land transition. However, this long-standing view has not been rigorously evaluated as hematopoietic sites remain poorly understood in most invertebrate groups. We report, to our knowledge, the first discovery of abundant HSCs in adult mollusk shells, an invertebrate hematopoietic niche resembling vertebrate bone marrow (BM). Cell-lineage analysis and functional assays reveal the developmental origin of HSCs during larval shell formation and their participation in hemocyte-mediated shell regeneration and soft-body blood supply. Widespread skeleton-related HSC-like cells are found in diverse invertebrate groups and bony fish group, suggesting skeletons as a universal niche for animal HSCs and HSC-skeleton association preceding vertebrate water-to-land transition. Comparison of invertebrate and vertebrate skeletal HSCs enables the macroevolutionary profiling of a core-set of animal HSC regulators. Our findings would boost fundamental paradigm shifts for hematopoiesis and stem cell research in invertebrates and provide the redefined understanding of vertebrate BM evolution and water-to-land transition. |
| title | Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons. |
| topic | Animals Hematopoietic Stem Cells Stem Cell Niche Invertebrates Bone Marrow Hematopoiesis Cell Lineage Hemocytes Biological Evolution |
| url | https://pubmed.ncbi.nlm.nih.gov/40561015/ |