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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biomolecules
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40563511/ |
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| _version_ | 1868266186729324546 |
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| author | Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng |
| author_facet | Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng |
| collection | PubMed - marine biology |
| contents | Brianolide from Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NFκB and MAPK Pathways. Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng Dermatitis, Atopic Humans NF-kappa B Animals Anthozoa MAP Kinase Signaling System Mice Dinitrochlorobenzene Keratinocytes Disease Models, Animal HaCaT Cells Cytokines Skin Cell Line Atopic dermatitis (AD) is a common chronic skin disease affecting both children and adults. Currently lacking a clinical cure, AD presents significant physical and emotional challenges for patients and their families, substantially impacting their quality of life. This underscores significant unmet needs in AD management and highlights the necessity for developing effective therapeutic applications. Recently, several chlorine-containing active substances with promising pharmacological activity have been discovered in soft corals cultivated through coral farming. Among these, brianolide, isolated from the soft coral , has shown promising potential. This study investigated brianolide's regulatory effects on the inflammatory response in atopic dermatitis and its underlying mechanisms. Using an in vitro human keratinocyte cell line (HaCaT) stimulated with tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ) to mimic AD inflammation, brianolide was found to inhibit cytokine and chemokine expression via the mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB)-signaling pathways. In an in vivo animal model of 2,4-Dinitrochlorobenzene (DNCB)-induced AD, brianolide demonstrated anti-inflammatory effects, reducing transepidermal water loss (TEWL), ear thickness, erythema, and epidermal blood flow. These findings provide new insights into brianolide's activity against AD-related inflammation, elucidate potential mechanisms, and contribute to understanding the pharmacological potential of natural coral products for AD treatment. |
| format | Artículo científico |
| id | pubmed_40563511 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Biomolecules |
| record_format | pubmed |
| spellingShingle | Brianolide from Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NFκB and MAPK Pathways. Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng Dermatitis, Atopic Humans NF-kappa B Animals Anthozoa MAP Kinase Signaling System Mice Dinitrochlorobenzene Keratinocytes Disease Models, Animal HaCaT Cells Cytokines Skin Cell Line Brianolide from Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NFκB and MAPK Pathways. Wang, Chia-Chen Wang, Kang-Ling Hsu, Yu-Jou Sung, Chao-Hsien Chen, Mei-Jung Huang, Meng-Fang Sung, Ping-Jyun Hung, Chi-Feng Dermatitis, Atopic Humans NF-kappa B Animals Anthozoa MAP Kinase Signaling System Mice Dinitrochlorobenzene Keratinocytes Disease Models, Animal HaCaT Cells Cytokines Skin Cell Line Atopic dermatitis (AD) is a common chronic skin disease affecting both children and adults. Currently lacking a clinical cure, AD presents significant physical and emotional challenges for patients and their families, substantially impacting their quality of life. This underscores significant unmet needs in AD management and highlights the necessity for developing effective therapeutic applications. Recently, several chlorine-containing active substances with promising pharmacological activity have been discovered in soft corals cultivated through coral farming. Among these, brianolide, isolated from the soft coral , has shown promising potential. This study investigated brianolide's regulatory effects on the inflammatory response in atopic dermatitis and its underlying mechanisms. Using an in vitro human keratinocyte cell line (HaCaT) stimulated with tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ) to mimic AD inflammation, brianolide was found to inhibit cytokine and chemokine expression via the mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB)-signaling pathways. In an in vivo animal model of 2,4-Dinitrochlorobenzene (DNCB)-induced AD, brianolide demonstrated anti-inflammatory effects, reducing transepidermal water loss (TEWL), ear thickness, erythema, and epidermal blood flow. These findings provide new insights into brianolide's activity against AD-related inflammation, elucidate potential mechanisms, and contribute to understanding the pharmacological potential of natural coral products for AD treatment. |
| title | Brianolide from Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NFκB and MAPK Pathways. |
| topic | Dermatitis, Atopic Humans NF-kappa B Animals Anthozoa MAP Kinase Signaling System Mice Dinitrochlorobenzene Keratinocytes Disease Models, Animal HaCaT Cells Cytokines Skin Cell Line |
| url | https://pubmed.ncbi.nlm.nih.gov/40563511/ |