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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish & shellfish immunology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40571069/ |
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| _version_ | 1868266186704158721 |
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| author | Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong |
| author_facet | Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong |
| collection | PubMed - marine biology |
| contents | Mudskipper β-def2 exhibits potent broad-spectrum bactericidal activity via membrane-disrupting and DNA-targeting mechanisms. Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong Animals beta-Defensins Anti-Bacterial Agents Phylogeny Amino Acid Sequence Polychaeta Microbial Sensitivity Tests Cell Membrane Sequence Alignment Defensins, cysteine-rich host defense peptides critical for host's antibacterial immunity, remain understudied in intertidal living species. Here, we characterize muβ-def2, a 43-amino-acid β-defensin from mudskipper with three pairs of disulfide structures (C1-C5, C2-C4, C3-C6) and a cationic amphiphilic topology, featuring a hydrophobic face and a charge-rich surface (+4.5 net charge, pI 8.9). Phylogenetic analysis reveals its tight clustering within the β-def2 subclass, highlighting conserved evolutionary antimicrobial functions. muβ-def2 exhibits potent broad-spectrum bactericidal activity, with minimum bactericidal concentrations (MBCs) ranging from |
| format | Artículo científico |
| id | pubmed_40571069 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | Mudskipper β-def2 exhibits potent broad-spectrum bactericidal activity via membrane-disrupting and DNA-targeting mechanisms. Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong Animals beta-Defensins Anti-Bacterial Agents Phylogeny Amino Acid Sequence Polychaeta Microbial Sensitivity Tests Cell Membrane Sequence Alignment Mudskipper β-def2 exhibits potent broad-spectrum bactericidal activity via membrane-disrupting and DNA-targeting mechanisms. Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong Animals beta-Defensins Anti-Bacterial Agents Phylogeny Amino Acid Sequence Polychaeta Microbial Sensitivity Tests Cell Membrane Sequence Alignment Defensins, cysteine-rich host defense peptides critical for host's antibacterial immunity, remain understudied in intertidal living species. Here, we characterize muβ-def2, a 43-amino-acid β-defensin from mudskipper with three pairs of disulfide structures (C1-C5, C2-C4, C3-C6) and a cationic amphiphilic topology, featuring a hydrophobic face and a charge-rich surface (+4.5 net charge, pI 8.9). Phylogenetic analysis reveals its tight clustering within the β-def2 subclass, highlighting conserved evolutionary antimicrobial functions. muβ-def2 exhibits potent broad-spectrum bactericidal activity, with minimum bactericidal concentrations (MBCs) ranging from |
| title | Mudskipper β-def2 exhibits potent broad-spectrum bactericidal activity via membrane-disrupting and DNA-targeting mechanisms. |
| topic | Animals beta-Defensins Anti-Bacterial Agents Phylogeny Amino Acid Sequence Polychaeta Microbial Sensitivity Tests Cell Membrane Sequence Alignment |
| url | https://pubmed.ncbi.nlm.nih.gov/40571069/ |