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| Autores principales: | , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Fish & shellfish immunology
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40571069/ |
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- Mudskipper β-def2 exhibits potent broad-spectrum bactericidal activity via membrane-disrupting and DNA-targeting mechanisms. Hu, Ya-Zhen Tan, Ning-Xi Cao, Jia-Feng Chen, Jiong Animals beta-Defensins Anti-Bacterial Agents Phylogeny Amino Acid Sequence Polychaeta Microbial Sensitivity Tests Cell Membrane Sequence Alignment Defensins, cysteine-rich host defense peptides critical for host's antibacterial immunity, remain understudied in intertidal living species. Here, we characterize muβ-def2, a 43-amino-acid β-defensin from mudskipper with three pairs of disulfide structures (C1-C5, C2-C4, C3-C6) and a cationic amphiphilic topology, featuring a hydrophobic face and a charge-rich surface (+4.5 net charge, pI 8.9). Phylogenetic analysis reveals its tight clustering within the β-def2 subclass, highlighting conserved evolutionary antimicrobial functions. muβ-def2 exhibits potent broad-spectrum bactericidal activity, with minimum bactericidal concentrations (MBCs) ranging from