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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecular pharmaceutics
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40592545/ |
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| _version_ | 1868266184091107329 |
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| author | Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula |
| author_facet | Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula |
| collection | PubMed - marine biology |
| contents | Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae. Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula Humans Cell Line, Tumor Nanoparticles Indoles Poloxamer Pancreatic Neoplasms Apoptosis Caulerpa Drug Delivery Systems Antineoplastic Agents Pancreatic cancer remains one of the deadliest cancers due to its resistance to conventional therapies, necessitating the development of novel treatment strategies. This study investigates the anticancer potential of caulerpin, a bisindole alkaloid derived from the invasive marine alga , encapsulated in biocompatible cubosomes. Caulerpin was sustainably extracted via microwave-assisted methods and formulated into lipid-based bicontinuous cubic liquid crystalline nanoparticles using Pluronic-free surfactants (sodium taurocholate and Span 80), resulting in high encapsulation efficiency and structural stability at physiological temperature (37 °C). The formulation included cubosomes coexisting with L3 sponge nanoparticles and vesicles. studies on BxPC-3 pancreatic cancer cells demonstrated that encapsulated caulerpin significantly outperformed the free compound, inducing marked apoptotic features such as cytoskeletal disruption and cell shrinkage, as confirmed by holotomographic microscopy and F-actin bioimaging. The enhanced therapeutic efficacy is attributed to the improved protection and sustained intracellular availability of encapsulated caulerpin, which is not rapidly metabolized as in its free form. These findings suggest that caulerpin-loaded cubosomes may represent a promising nanotechnology-based strategy for pancreatic cancer treatment. |
| format | Artículo científico |
| id | pubmed_40592545 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Molecular pharmaceutics |
| record_format | pubmed |
| spellingShingle | Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae. Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula Humans Cell Line, Tumor Nanoparticles Indoles Poloxamer Pancreatic Neoplasms Apoptosis Caulerpa Drug Delivery Systems Antineoplastic Agents Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae. Krautforst, Karolina Kulbacka, Julita Fornasier, Marco Mocci, Rita Porcheddu, Andrea Pusceddu, Antonio Moccia, Davide Murgia, Sergio Bazylińska, Urszula Humans Cell Line, Tumor Nanoparticles Indoles Poloxamer Pancreatic Neoplasms Apoptosis Caulerpa Drug Delivery Systems Antineoplastic Agents Pancreatic cancer remains one of the deadliest cancers due to its resistance to conventional therapies, necessitating the development of novel treatment strategies. This study investigates the anticancer potential of caulerpin, a bisindole alkaloid derived from the invasive marine alga , encapsulated in biocompatible cubosomes. Caulerpin was sustainably extracted via microwave-assisted methods and formulated into lipid-based bicontinuous cubic liquid crystalline nanoparticles using Pluronic-free surfactants (sodium taurocholate and Span 80), resulting in high encapsulation efficiency and structural stability at physiological temperature (37 °C). The formulation included cubosomes coexisting with L3 sponge nanoparticles and vesicles. studies on BxPC-3 pancreatic cancer cells demonstrated that encapsulated caulerpin significantly outperformed the free compound, inducing marked apoptotic features such as cytoskeletal disruption and cell shrinkage, as confirmed by holotomographic microscopy and F-actin bioimaging. The enhanced therapeutic efficacy is attributed to the improved protection and sustained intracellular availability of encapsulated caulerpin, which is not rapidly metabolized as in its free form. These findings suggest that caulerpin-loaded cubosomes may represent a promising nanotechnology-based strategy for pancreatic cancer treatment. |
| title | Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae. |
| topic | Humans Cell Line, Tumor Nanoparticles Indoles Poloxamer Pancreatic Neoplasms Apoptosis Caulerpa Drug Delivery Systems Antineoplastic Agents |
| url | https://pubmed.ncbi.nlm.nih.gov/40592545/ |