Synthesis of Alkyl (-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement.
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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
The Journal of organic chemistry
2025
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| _version_ | 1868266181680431105 |
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| author | Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng |
| author_facet | Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng |
| collection | PubMed - marine biology |
| contents | Synthesis of Alkyl (-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement. Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng An atom-economical and chemoselective synthesis of alkyl (-benzyl)-aryl sulfoxides has been developed. Sulfenate anions, which were generated by the Truce-Smiles rearrangement of heteroaryl (-alkyl)-aryl sulfoxides, have been trapped by primary alkyl halides to deliver the corresponding sulfoxides. A Truce-Smiles rearrangement/cyclization cascade has been designed to expand the scope of secondary cycloalkyl sulfoxides. |
| format | Artículo científico |
| id | pubmed_40611558 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | The Journal of organic chemistry |
| record_format | pubmed |
| spellingShingle | Synthesis of Alkyl (-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement. Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng Synthesis of Alkyl (-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement. Zhang, Zhaoqing Zhang, Xinping Jia, Runyu Jia, Tiezheng An atom-economical and chemoselective synthesis of alkyl (-benzyl)-aryl sulfoxides has been developed. Sulfenate anions, which were generated by the Truce-Smiles rearrangement of heteroaryl (-alkyl)-aryl sulfoxides, have been trapped by primary alkyl halides to deliver the corresponding sulfoxides. A Truce-Smiles rearrangement/cyclization cascade has been designed to expand the scope of secondary cycloalkyl sulfoxides. |
| title | Synthesis of Alkyl (-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement. |
| url | https://pubmed.ncbi.nlm.nih.gov/40611558/ |