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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Apoptosis : an international journal on programmed cell death
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40618003/ |
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| _version_ | 1868266181669945344 |
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| author | Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng |
| author_facet | Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng |
| collection | PubMed - marine biology |
| contents | Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy. Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng Humans Animals Aspirin Antineoplastic Agents Apoptosis Mice Acetylglucosamine Xenograft Model Antitumor Assays Cell Line, Tumor Colorectal Neoplasms Female Cell Movement Mice, Nude Male Mice, Inbred BALB C Cell Proliferation Pancreatic Neoplasms Cell Survival Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therapeutic. However, its clinical application is hindered by severe adverse effects. Here, we explore 6-O-Carboxymethyl-N-Acetylglucosamine (CM-NAG) a novel derivative of N-acetylglucosamine, designed to mimic the structural and functional properties of aspirin. CM-NAG significantly inhibits the viability of both colorectal and pancreatic cancer cells. In colorectal cancer cells, CM-NAG also suppressed migration and invasion and induced apoptosis more effectively than aspirin. Mechanistically, CM-NAG upregulated phosphoenolpyruvate carboxykinase 2 (PCK2), a key regulator of gluconeogenesis in colorectal cancer cells. In a xenograft model, CM-NAG reduced tumor size and improved histopathological outcomes, while showing no significant toxicity in major organs. The expression of PCK2 in CRC tissues was significantly lower than in cancer-adjacent tissues, according immunohistochemistry analysis. Clinical analysis revealed high PCK2 expression in colorectal cancer tissues correlates with better disease-free survival, supporting PCK2 as a promising therapeutic target. These findings suggest that CM-NAG may represent a next-generation antitumor agent with enhanced efficacy and safety compared to aspirin, offering new prospects for cancer treatment. |
| format | Artículo científico |
| id | pubmed_40618003 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Apoptosis : an international journal on programmed cell death |
| record_format | pubmed |
| spellingShingle | Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy. Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng Humans Animals Aspirin Antineoplastic Agents Apoptosis Mice Acetylglucosamine Xenograft Model Antitumor Assays Cell Line, Tumor Colorectal Neoplasms Female Cell Movement Mice, Nude Male Mice, Inbred BALB C Cell Proliferation Pancreatic Neoplasms Cell Survival Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy. Qiao, Ziwen Zhang, Guangmin Chen, Xin Zhang, Yuefa Zhang, Sudan Qin, Xiuheng Sohail, Ammara Xu, Xiaohui Liu, Jiane Han, Baoqin Wang, Daijie Zhang, Xiangyan Wang, Zheng Humans Animals Aspirin Antineoplastic Agents Apoptosis Mice Acetylglucosamine Xenograft Model Antitumor Assays Cell Line, Tumor Colorectal Neoplasms Female Cell Movement Mice, Nude Male Mice, Inbred BALB C Cell Proliferation Pancreatic Neoplasms Cell Survival Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therapeutic. However, its clinical application is hindered by severe adverse effects. Here, we explore 6-O-Carboxymethyl-N-Acetylglucosamine (CM-NAG) a novel derivative of N-acetylglucosamine, designed to mimic the structural and functional properties of aspirin. CM-NAG significantly inhibits the viability of both colorectal and pancreatic cancer cells. In colorectal cancer cells, CM-NAG also suppressed migration and invasion and induced apoptosis more effectively than aspirin. Mechanistically, CM-NAG upregulated phosphoenolpyruvate carboxykinase 2 (PCK2), a key regulator of gluconeogenesis in colorectal cancer cells. In a xenograft model, CM-NAG reduced tumor size and improved histopathological outcomes, while showing no significant toxicity in major organs. The expression of PCK2 in CRC tissues was significantly lower than in cancer-adjacent tissues, according immunohistochemistry analysis. Clinical analysis revealed high PCK2 expression in colorectal cancer tissues correlates with better disease-free survival, supporting PCK2 as a promising therapeutic target. These findings suggest that CM-NAG may represent a next-generation antitumor agent with enhanced efficacy and safety compared to aspirin, offering new prospects for cancer treatment. |
| title | Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy. |
| topic | Humans Animals Aspirin Antineoplastic Agents Apoptosis Mice Acetylglucosamine Xenograft Model Antitumor Assays Cell Line, Tumor Colorectal Neoplasms Female Cell Movement Mice, Nude Male Mice, Inbred BALB C Cell Proliferation Pancreatic Neoplasms Cell Survival |
| url | https://pubmed.ncbi.nlm.nih.gov/40618003/ |