Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Beilstein journal of organic chemistry
2025
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40626212/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- -Salicyl-amino acid derivatives with antiparasitic activity from sp. UIAU-6B. Rajakulendran, Joy E Oluwabusola, Emmanuel Tope Cerone, Michela Smith, Terry K Adebisi, Olusoji O Adedotun, Adefolalu Preet, Gagan Soldatou, Sylvia Deng, Hai Ebel, Rainer Jaspars, Marcel Pseudomonads strains represent a promising source of bioactive compounds with potential pharmaceutical applications. The necessity to find new drugs is underscored by the increased concern over antimicrobial resistance in the human system. In this study, we isolated two previously undescribed -salicyl-amino acids as natural products ( and ) and other two new derivatives ( and ) from the organic extract of a culture broth in a modified starch-glucose-glycerol (SGG) medium of sp. UIAU-6B. The structure of the new natural products, pseudomonins D-G (-) isolated alongside other three known compounds, pseudomonine (), pseudomonin B () and salicylic acid (), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configurations of the threonine residue in compounds and were determined by Marfey's analysis. Compound displayed a very weak pan-trypanocidal activity against with EC values of 101-137 μM, while compounds and showed modest activity against but none of the remaining compounds showed activity at the highest concentrations tested. The plausible biosynthetic hypotheses toward the compounds were also proposed.