Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity.
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PubMed
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
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Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2025
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| _version_ | 1868266179240394754 |
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| author | Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan |
| author_facet | Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan |
| collection | PubMed - marine biology |
| contents | Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity. Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan Animals Mice T-Lymphocytes Immunotherapy Mice, Inbred C57BL Cell Line, Tumor Neoplasms Humans Female T lymphocytes are pivotal targets in clinical cancer immunotherapy; however, tumor cells frequently evade the T-cell attacks by altering the intrinsic immunogenicity manifested as adjuvanticity, antigenicity, and reactogenicity. Here, a bacterial outer membrane vesicle (OMVs)-based nanosystem is presented to elicit robust T-cell responses by reshaping tumor immunogenicity. OMVs are engineered with vesicular stomatitis virus G-protein that facilitates the fusion of OMVs with tumor cells, leading to tumor "foreignization" and adjuvanticity augment. Consequently, the innate immune system is mobilized to sense the foreignized tumor cells and present the whole-cell tumor antigens, significantly improving the tumor antigenicity and priming multi-phenotypic T cells, including both pathogen-specific and tumor-specific T cells. Meanwhile, the tumor reactogenicity is reinvigorated through direct cytoplasmic delivery of siPD-L1 during the fusion, amplifying T cells-mediated cytotoxicity. In murine models, this foreignization strategy potentiates adaptive immunity and induces durable immune memory, thus effectively suppressing bilateral and metastatic tumors, demonstrating its therapeutic potential in comprehensively reprogramming tumor immunogenicity to fight cancer. |
| format | Artículo científico |
| id | pubmed_40637269 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
| record_format | pubmed |
| spellingShingle | Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity. Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan Animals Mice T-Lymphocytes Immunotherapy Mice, Inbred C57BL Cell Line, Tumor Neoplasms Humans Female Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity. Zhuang, Wan-Ru Xue, Wen-Chi Liang, Chao Liu, Pan Lei, Yao He, Jiaqi Cheng, Ran Nie, Weidong Wang, Jianxiong Tang, Jie Xie, Hai-Yan Animals Mice T-Lymphocytes Immunotherapy Mice, Inbred C57BL Cell Line, Tumor Neoplasms Humans Female T lymphocytes are pivotal targets in clinical cancer immunotherapy; however, tumor cells frequently evade the T-cell attacks by altering the intrinsic immunogenicity manifested as adjuvanticity, antigenicity, and reactogenicity. Here, a bacterial outer membrane vesicle (OMVs)-based nanosystem is presented to elicit robust T-cell responses by reshaping tumor immunogenicity. OMVs are engineered with vesicular stomatitis virus G-protein that facilitates the fusion of OMVs with tumor cells, leading to tumor "foreignization" and adjuvanticity augment. Consequently, the innate immune system is mobilized to sense the foreignized tumor cells and present the whole-cell tumor antigens, significantly improving the tumor antigenicity and priming multi-phenotypic T cells, including both pathogen-specific and tumor-specific T cells. Meanwhile, the tumor reactogenicity is reinvigorated through direct cytoplasmic delivery of siPD-L1 during the fusion, amplifying T cells-mediated cytotoxicity. In murine models, this foreignization strategy potentiates adaptive immunity and induces durable immune memory, thus effectively suppressing bilateral and metastatic tumors, demonstrating its therapeutic potential in comprehensively reprogramming tumor immunogenicity to fight cancer. |
| title | Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity. |
| topic | Animals Mice T-Lymphocytes Immunotherapy Mice, Inbred C57BL Cell Line, Tumor Neoplasms Humans Female |
| url | https://pubmed.ncbi.nlm.nih.gov/40637269/ |