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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic letters
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40668106/ |
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| _version_ | 1868266176823427073 |
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| author | Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua |
| author_facet | Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua |
| collection | PubMed - marine biology |
| contents | Discovery, Structural Revision, Heterologous Production, and Biosynthesis of Mintaimycins from Marine-Derived sp. SCSIO 80128. Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua Micromonospora Molecular Structure Multigene Family Biological Products , a large group of actinomycetes, is increasingly important in natural products discovery. Genus-based metabologenomic analyses and OSMAC tactics unveiled three known (, , and ) and three new mintaimycins (, , and ) from marine-derived sp. SCSIO 80128. All absolute configurations were unambiguously established by X-ray diffraction and their biosynthetic gene cluster () was validated by heterologous expression. Bioinformatics and gene inactivation studies support a newly proposed biosynthetic pathway to -. |
| format | Artículo científico |
| id | pubmed_40668106 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Organic letters |
| record_format | pubmed |
| spellingShingle | Discovery, Structural Revision, Heterologous Production, and Biosynthesis of Mintaimycins from Marine-Derived sp. SCSIO 80128. Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua Micromonospora Molecular Structure Multigene Family Biological Products Discovery, Structural Revision, Heterologous Production, and Biosynthesis of Mintaimycins from Marine-Derived sp. SCSIO 80128. Li, Xiaohua Zhou, Zhenbin Yang, Jiafan Sun, Changli Tian, Xinpeng Ma, Junying Ju, Jianhua Micromonospora Molecular Structure Multigene Family Biological Products , a large group of actinomycetes, is increasingly important in natural products discovery. Genus-based metabologenomic analyses and OSMAC tactics unveiled three known (, , and ) and three new mintaimycins (, , and ) from marine-derived sp. SCSIO 80128. All absolute configurations were unambiguously established by X-ray diffraction and their biosynthetic gene cluster () was validated by heterologous expression. Bioinformatics and gene inactivation studies support a newly proposed biosynthetic pathway to -. |
| title | Discovery, Structural Revision, Heterologous Production, and Biosynthesis of Mintaimycins from Marine-Derived sp. SCSIO 80128. |
| topic | Micromonospora Molecular Structure Multigene Family Biological Products |
| url | https://pubmed.ncbi.nlm.nih.gov/40668106/ |