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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish & shellfish immunology
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40691980/ |
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| _version_ | 1868266174432673792 |
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| author | Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun |
| author_facet | Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun |
| collection | PubMed - marine biology |
| contents | CC25-like from Cromileptes altivelis (CaCC25-like) promotes antimicrobial immunity defense through chemotactic and direct antibacterial activity. Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun Animals Fish Diseases Immunity, Innate Fish Proteins Vibrio Vibrio Infections Phylogeny Sequence Alignment Amino Acid Sequence Chemotaxis Gene Expression Regulation Perciformes Gene Expression Profiling Streptococcal Infections The humpback grouper (Cromileptes altivelis), a high-value marine species, encounters substantial challenges in aquaculture due to frequent disease outbreaks and elevated mortality rates. Chemokines, which serve as pivotal mediators of both innate and adaptive immunity, play an essential role in orchestrating leukocyte migration and pathogen clearance. However, their functional roles remain poorly characterized compared to those in mammals. In this study, we identified a CC25-like gene in C. altivelis (CaCC25-like) and investigated its immune-related functions. The CaCC25-like encodes a 96-amino-acid protein that contains a conserved SCY domain and NCCL motif, showing high homology to teleost CC25 orthologs (42.45 %-97.92 %) but low similarity to mammalian CC25 ( |
| format | Artículo científico |
| id | pubmed_40691980 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Fish & shellfish immunology |
| record_format | pubmed |
| spellingShingle | CC25-like from Cromileptes altivelis (CaCC25-like) promotes antimicrobial immunity defense through chemotactic and direct antibacterial activity. Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun Animals Fish Diseases Immunity, Innate Fish Proteins Vibrio Vibrio Infections Phylogeny Sequence Alignment Amino Acid Sequence Chemotaxis Gene Expression Regulation Perciformes Gene Expression Profiling Streptococcal Infections CC25-like from Cromileptes altivelis (CaCC25-like) promotes antimicrobial immunity defense through chemotactic and direct antibacterial activity. Du, Hehe Xiang, Yajing Zheng, Jingwen Chen, Guisen Zhang, Panpan Ao, Jingqun Zhou, Yongcan Sun, Yun Animals Fish Diseases Immunity, Innate Fish Proteins Vibrio Vibrio Infections Phylogeny Sequence Alignment Amino Acid Sequence Chemotaxis Gene Expression Regulation Perciformes Gene Expression Profiling Streptococcal Infections The humpback grouper (Cromileptes altivelis), a high-value marine species, encounters substantial challenges in aquaculture due to frequent disease outbreaks and elevated mortality rates. Chemokines, which serve as pivotal mediators of both innate and adaptive immunity, play an essential role in orchestrating leukocyte migration and pathogen clearance. However, their functional roles remain poorly characterized compared to those in mammals. In this study, we identified a CC25-like gene in C. altivelis (CaCC25-like) and investigated its immune-related functions. The CaCC25-like encodes a 96-amino-acid protein that contains a conserved SCY domain and NCCL motif, showing high homology to teleost CC25 orthologs (42.45 %-97.92 %) but low similarity to mammalian CC25 ( |
| title | CC25-like from Cromileptes altivelis (CaCC25-like) promotes antimicrobial immunity defense through chemotactic and direct antibacterial activity. |
| topic | Animals Fish Diseases Immunity, Innate Fish Proteins Vibrio Vibrio Infections Phylogeny Sequence Alignment Amino Acid Sequence Chemotaxis Gene Expression Regulation Perciformes Gene Expression Profiling Streptococcal Infections |
| url | https://pubmed.ncbi.nlm.nih.gov/40691980/ |