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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
DNA research : an international journal for rapid publication of reports on genes and genomes
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40693514/ |
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| _version_ | 1868266174428479488 |
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| author | Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua |
| author_facet | Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua |
| collection | PubMed - marine biology |
| contents | Dynamic integration and evolutionary trajectory of endogenous IHHNV elements in crustacean genomes. Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua Animals Evolution, Molecular Crustacea Genome Phylogeny Virus Integration Endogenous viral elements (EVEs) serve as molecular fossils that record the ancient co-evolutionary arms race between viruses and their hosts. In this study, by analyzing 105 host crustacean genomes, we identified 252 infectious hypodermal and haematopoietic necrosis virus-derived EVEs (IHHNV-EVEs), which include 183 ancient and 6 recently inserted EVEs. These IHHNV-EVEs are widely distributed among Decapoda, Thoracica, and Isopoda, with some of them exhibiting a syntenic distribution relative to neighboring host sequences, suggesting that the IHHNV or its ancestor are potential pathogens of these species with a long-time dynamic interaction during the evolutionary history. An expansion of IHHNV-EVEs was observed in decapoda genomes, reflecting a reinforced arm race between decapoda and IHHNV. Notably, we found that nearly all recent IHHNV-EVEs were laboratory contaminants, except for a single authentic integration in Penaeus monodon that persists intact across 16 samples from the 2 populations. These temporal dynamics-ancient genomic stabilization versus modern colonization activity-highlight that EVEs serve as dual archives: historical records of past conflicts and active participants in current evolutionary battles. Our findings redefine viral genomic colonization as a continuum, where ancient EVE fixation coexists with persistent integration processes, providing new insights into host-virus co-evolutionary trajectories. |
| format | Artículo científico |
| id | pubmed_40693514 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | DNA research : an international journal for rapid publication of reports on genes and genomes |
| record_format | pubmed |
| spellingShingle | Dynamic integration and evolutionary trajectory of endogenous IHHNV elements in crustacean genomes. Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua Animals Evolution, Molecular Crustacea Genome Phylogeny Virus Integration Dynamic integration and evolutionary trajectory of endogenous IHHNV elements in crustacean genomes. Zhong, Xiaoyun Yuan, Jianbo Zhang, Xiaojun Li, Shihao Liu, Chengzhang Si, Shuqing Hu, Jie Prachumwat, Anuphap Sritunyalucksana, Kallaya Li, Fuhua Animals Evolution, Molecular Crustacea Genome Phylogeny Virus Integration Endogenous viral elements (EVEs) serve as molecular fossils that record the ancient co-evolutionary arms race between viruses and their hosts. In this study, by analyzing 105 host crustacean genomes, we identified 252 infectious hypodermal and haematopoietic necrosis virus-derived EVEs (IHHNV-EVEs), which include 183 ancient and 6 recently inserted EVEs. These IHHNV-EVEs are widely distributed among Decapoda, Thoracica, and Isopoda, with some of them exhibiting a syntenic distribution relative to neighboring host sequences, suggesting that the IHHNV or its ancestor are potential pathogens of these species with a long-time dynamic interaction during the evolutionary history. An expansion of IHHNV-EVEs was observed in decapoda genomes, reflecting a reinforced arm race between decapoda and IHHNV. Notably, we found that nearly all recent IHHNV-EVEs were laboratory contaminants, except for a single authentic integration in Penaeus monodon that persists intact across 16 samples from the 2 populations. These temporal dynamics-ancient genomic stabilization versus modern colonization activity-highlight that EVEs serve as dual archives: historical records of past conflicts and active participants in current evolutionary battles. Our findings redefine viral genomic colonization as a continuum, where ancient EVE fixation coexists with persistent integration processes, providing new insights into host-virus co-evolutionary trajectories. |
| title | Dynamic integration and evolutionary trajectory of endogenous IHHNV elements in crustacean genomes. |
| topic | Animals Evolution, Molecular Crustacea Genome Phylogeny Virus Integration |
| url | https://pubmed.ncbi.nlm.nih.gov/40693514/ |