Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40697044/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266174421139457 |
|---|---|
| author | Liu, Ge Shan, Yeqi Sun, Chaomin |
| author_facet | Liu, Ge Shan, Yeqi Sun, Chaomin Liu, Ge Shan, Yeqi Sun, Chaomin |
| collection | PubMed - marine biology |
| contents | A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects. Liu, Ge Shan, Yeqi Sun, Chaomin Pyroptosis Humans Animals Mice Antineoplastic Agents Polysaccharides, Bacterial THP-1 Cells Cell Line, Tumor Inflammasomes NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis is an inflammatory programmed cell death. In recent years, the potential of pyroptosis in tumor treatment has received widespread attention and has become a promising anti-tumor therapeutic strategy. EPS3.9 is a novel deep-sea bacterial exopolysaccharide that we obtained and has potent anti-tumor activity. EPS3.9 consisted of mannose and glucose with a molar ratio of 1:0.42. The average molecular weight of EPS3.9 was 17.1 kDa. EPS3.9 can induce lytic cell death in tumor cells. Mechanism analysis has revealed that it can directly target 5 membrane phospholipids and exert tumor cytotoxic activity through triggering NLRP3 inflammasome-mediated pyroptosis in the human monocytic leukemia THP-1 cells. EPS3.9 also has significant anti-tumor effects in Huh7.5 tumor-bearing mice and can activate anti-tumor immune responses. Besides, this active exopolysaccharide is ubiquitous among the genus Spongiibacter. This study provides an important theoretical basis for EPS3.9 as a new type of marine carbohydrate anti-tumor drug candidate and also provides scientific evidence for the feasibility and potential of tumor treatment by triggering pyroptosis. |
| format | Artículo científico |
| id | pubmed_40697044 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | FASEB journal : official publication of the Federation of American Societies for Experimental Biology |
| record_format | pubmed |
| spellingShingle | A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects. Liu, Ge Shan, Yeqi Sun, Chaomin Pyroptosis Humans Animals Mice Antineoplastic Agents Polysaccharides, Bacterial THP-1 Cells Cell Line, Tumor Inflammasomes NLR Family, Pyrin Domain-Containing 3 Protein A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects. Liu, Ge Shan, Yeqi Sun, Chaomin Pyroptosis Humans Animals Mice Antineoplastic Agents Polysaccharides, Bacterial THP-1 Cells Cell Line, Tumor Inflammasomes NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis is an inflammatory programmed cell death. In recent years, the potential of pyroptosis in tumor treatment has received widespread attention and has become a promising anti-tumor therapeutic strategy. EPS3.9 is a novel deep-sea bacterial exopolysaccharide that we obtained and has potent anti-tumor activity. EPS3.9 consisted of mannose and glucose with a molar ratio of 1:0.42. The average molecular weight of EPS3.9 was 17.1 kDa. EPS3.9 can induce lytic cell death in tumor cells. Mechanism analysis has revealed that it can directly target 5 membrane phospholipids and exert tumor cytotoxic activity through triggering NLRP3 inflammasome-mediated pyroptosis in the human monocytic leukemia THP-1 cells. EPS3.9 also has significant anti-tumor effects in Huh7.5 tumor-bearing mice and can activate anti-tumor immune responses. Besides, this active exopolysaccharide is ubiquitous among the genus Spongiibacter. This study provides an important theoretical basis for EPS3.9 as a new type of marine carbohydrate anti-tumor drug candidate and also provides scientific evidence for the feasibility and potential of tumor treatment by triggering pyroptosis. |
| title | A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects. |
| topic | Pyroptosis Humans Animals Mice Antineoplastic Agents Polysaccharides, Bacterial THP-1 Cells Cell Line, Tumor Inflammasomes NLR Family, Pyrin Domain-Containing 3 Protein |
| url | https://pubmed.ncbi.nlm.nih.gov/40697044/ |