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| Autores principales: | , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Marine drugs
2025
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| Materias: | |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/40710491/ |
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- Diversity and Novelty of Venom Peptides in Vermivorous Cone Snails, Subgenus (Gastropoda: Mollusca). Florece, Christine Marie C Kaas, Quentin Barghi, Neda Lluisma, Arturo O Animals Conus Snail Peptides Transcriptome Philippines Mollusk Venoms Conotoxins Phylogeny A large majority of cone snails (a species in the genus ) are vermivorous (worm-hunting), but the diversity and bioactivity of their venom peptides remain largely unexplored. In this study, we report the first venom gland transcriptomes from two species in the clade, and , and a new transcriptome from a specimen collected in the Philippines. From the set of assembled sequences, a total of 225 , 121 , and 168 putative peptide toxin transcripts were identified, which were assigned to 27 canonical gene superfamilies in and 24 in and in . Most of these venom peptides are novel, and some exhibit new cysteine patterns. Clustering also revealed 12 putative novel gene superfamilies, highlighting the diversity of uncharacterized venom peptides in this group. The O1-, M-, O2-, and con-ikot-ikot superfamilies were the most abundant, while gene superfamilies such as D and G2 were highly expressed. Several hormone-like conopeptides were also identified in this study, revealing the vast diversity of conopeptides from the species.