Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40710503/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266174400167938 |
|---|---|
| author | Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina |
| author_facet | Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina |
| collection | PubMed - marine biology |
| contents | Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina Animals Chalcones Mice Anti-Inflammatory Agents Skin Aging Seaweed Macrophages Cosmetics RAW 264.7 Cells Nitric Oxide Synthase Type II NF-E2-Related Factor 2 Keratinocytes Humans Structure-Activity Relationship Inflammation Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol , we investigated the anti-inflammatory potential of structure-related chalcones (-). Chalcones and showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones , , , and exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone having the lowest IC value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging. Symmetrical bromine atoms and 3,4-dimethoxy groups on both aromatic rings improved the anti-inflammatory activity, indicating a relevant structure-activity relationship. Chalcones and were selected for study to clarify their mechanisms of action. At a concentration of 7.5 μM, chalcone demonstrated a rapid and effective inhibitory action on the protein levels of inducible nitric oxide synthase (iNOS), while chalcone exhibited a gradual inhibitory action. Moreover, chalcone effectively activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway with around a 3.5-fold increase at the end of 24 h at 7.5 μM, highlighting its potential as a modulator of oxidative stress responses. These findings place chalcone as a promising candidate for skincare products targeting inflammation and skin aging. |
| format | Artículo científico |
| id | pubmed_40710503 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina Animals Chalcones Mice Anti-Inflammatory Agents Skin Aging Seaweed Macrophages Cosmetics RAW 264.7 Cells Nitric Oxide Synthase Type II NF-E2-Related Factor 2 Keratinocytes Humans Structure-Activity Relationship Inflammation Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina Animals Chalcones Mice Anti-Inflammatory Agents Skin Aging Seaweed Macrophages Cosmetics RAW 264.7 Cells Nitric Oxide Synthase Type II NF-E2-Related Factor 2 Keratinocytes Humans Structure-Activity Relationship Inflammation Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol , we investigated the anti-inflammatory potential of structure-related chalcones (-). Chalcones and showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones , , , and exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone having the lowest IC value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging. Symmetrical bromine atoms and 3,4-dimethoxy groups on both aromatic rings improved the anti-inflammatory activity, indicating a relevant structure-activity relationship. Chalcones and were selected for study to clarify their mechanisms of action. At a concentration of 7.5 μM, chalcone demonstrated a rapid and effective inhibitory action on the protein levels of inducible nitric oxide synthase (iNOS), while chalcone exhibited a gradual inhibitory action. Moreover, chalcone effectively activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway with around a 3.5-fold increase at the end of 24 h at 7.5 μM, highlighting its potential as a modulator of oxidative stress responses. These findings place chalcone as a promising candidate for skincare products targeting inflammation and skin aging. |
| title | Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. |
| topic | Animals Chalcones Mice Anti-Inflammatory Agents Skin Aging Seaweed Macrophages Cosmetics RAW 264.7 Cells Nitric Oxide Synthase Type II NF-E2-Related Factor 2 Keratinocytes Humans Structure-Activity Relationship Inflammation |
| url | https://pubmed.ncbi.nlm.nih.gov/40710503/ |