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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2025
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/40710503/ |
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Table of Contents:
- Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. Jesus, Ana Gimondi, Sara Pinho, Sónia A Ferreira, Helena Neves, Nuno M Palmeira, Andreia Sousa, Emília Almeida, Isabel F Cruz, Maria T Cidade, Honorina Animals Chalcones Mice Anti-Inflammatory Agents Skin Aging Seaweed Macrophages Cosmetics RAW 264.7 Cells Nitric Oxide Synthase Type II NF-E2-Related Factor 2 Keratinocytes Humans Structure-Activity Relationship Inflammation Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol , we investigated the anti-inflammatory potential of structure-related chalcones (-). Chalcones and showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones , , , and exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone having the lowest IC value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging. Symmetrical bromine atoms and 3,4-dimethoxy groups on both aromatic rings improved the anti-inflammatory activity, indicating a relevant structure-activity relationship. Chalcones and were selected for study to clarify their mechanisms of action. At a concentration of 7.5 μM, chalcone demonstrated a rapid and effective inhibitory action on the protein levels of inducible nitric oxide synthase (iNOS), while chalcone exhibited a gradual inhibitory action. Moreover, chalcone effectively activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway with around a 3.5-fold increase at the end of 24 h at 7.5 μM, highlighting its potential as a modulator of oxidative stress responses. These findings place chalcone as a promising candidate for skincare products targeting inflammation and skin aging.