Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates.
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| Format: | Artículo científico |
| Sprache: | en |
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Toxins
2025
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| author | Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani |
| author_facet | Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani |
| collection | PubMed - marine biology |
| contents | Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates. Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani Animals Microcystis Daphnia Artemia Ecotoxicology Microcystins Cyanobacterial blooms are becoming increasingly frequent and intense worldwide, often dominated by , a species capable of producing a wide array of bioactive metabolites beyond microcystins. This study evaluates the ecotoxicological potential of a non-microcystin-producing strain, CCIBt3106, using acute immobilization assays with three microcrustacean species: , , and . Biomass was extracted using solvents of varying polarity, and selected extracts (aqueous and 50% methanol) were further fractionated and analyzed via high-resolution liquid chromatography-tandem mass spectrometry (HR-LC-MS/MS). Significant toxicity was observed in and , with EC values ranging from 660 to 940 µg mL. Metabolomic profiling revealed the presence of chemically diverse metabolite classes, including peptides, polyketides, and fatty acyls, with putative annotations linked to known bioactivities. These findings demonstrate that cyanobacterial strains lacking microcystins can still produce complex metabolite mixtures capable of inducing species-specific toxic effects under environmentally relevant exposure levels. Overall, the results highlight the need to expand ecotoxicological assessments and monitoring frameworks to include non-microcystin cyanobacterial metabolites and strains in water quality management. |
| format | Artículo científico |
| id | pubmed_40711132 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Toxins |
| record_format | pubmed |
| spellingShingle | Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates. Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani Animals Microcystis Daphnia Artemia Ecotoxicology Microcystins Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates. Almeida, Éryka Costa Jacinavicius, Fernanda Rios Médice, Rhuana Valdetário Menezes, Rafaella Bizo Passos, Larissa Souza Anderson, Dominique Yoon, Jaewon Faria, Elaine Dias Crnkovic, Camila Manoel Fonseca, Ana Lúcia Henry, Theodore Pinto, Ernani Animals Microcystis Daphnia Artemia Ecotoxicology Microcystins Cyanobacterial blooms are becoming increasingly frequent and intense worldwide, often dominated by , a species capable of producing a wide array of bioactive metabolites beyond microcystins. This study evaluates the ecotoxicological potential of a non-microcystin-producing strain, CCIBt3106, using acute immobilization assays with three microcrustacean species: , , and . Biomass was extracted using solvents of varying polarity, and selected extracts (aqueous and 50% methanol) were further fractionated and analyzed via high-resolution liquid chromatography-tandem mass spectrometry (HR-LC-MS/MS). Significant toxicity was observed in and , with EC values ranging from 660 to 940 µg mL. Metabolomic profiling revealed the presence of chemically diverse metabolite classes, including peptides, polyketides, and fatty acyls, with putative annotations linked to known bioactivities. These findings demonstrate that cyanobacterial strains lacking microcystins can still produce complex metabolite mixtures capable of inducing species-specific toxic effects under environmentally relevant exposure levels. Overall, the results highlight the need to expand ecotoxicological assessments and monitoring frameworks to include non-microcystin cyanobacterial metabolites and strains in water quality management. |
| title | Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates. |
| topic | Animals Microcystis Daphnia Artemia Ecotoxicology Microcystins |
| url | https://pubmed.ncbi.nlm.nih.gov/40711132/ |