Lighting Up Healing: Green Light-Driven Dual Gasotransmitters Release against MRSA Wound Infections.
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Journal of the American Chemical Society
2025
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| _version_ | 1868266174394925056 |
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| author | Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao |
| author_facet | Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao |
| collection | PubMed - marine biology |
| contents | Lighting Up Healing: Green Light-Driven Dual Gasotransmitters Release against MRSA Wound Infections. Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao Methicillin-Resistant Staphylococcus aureus Wound Healing Anti-Bacterial Agents Wound Infection Light Nitric Oxide Carbon Monoxide Animals Staphylococcal Infections Rhodamines Microbial Sensitivity Tests Mice Humans Green Light Methicillin-resistant (MRSA) represents a major clinical challenge as a predominant pathogen causing chronic and difficult-to-treat wound infections. Effective strategies that simultaneously combat bacterial infection and promote tissue regeneration are essential yet challenging for managing MRSA-related wound complications. Herein, we report the design of a novel integrated dual-gas release molecular platform, which enable the phototriggered simultaneous release of NO and CO within a single molecular entity, i.e., an acylhydrazine-caged rhodamine (). Green light initiates the cascade release of NO and CO from , with a synchronized fluorescent turn-on signal, serving as an intrinsic calibration mechanism for real-time tracking of the localization, kinetics of dual gas release. The photodriven simultaneous release of NO and CO from demonstrates a superior antimicrobial effect against MRSA, while exhibiting excellent biocompatibility. By harnessing the synergistic and complementary bioactivities of NO and CO, effectively eradicates bacterial infections and promotes wound healing in a marine MRSA-infected skin wound model. This work highlights a promising noninvasive strategy for multigas simultaneous release therapy, providing a potent approach to tackling resistant bacterial infections and addressing broader biomedical challenges. |
| format | Artículo científico |
| id | pubmed_40711836 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Journal of the American Chemical Society |
| record_format | pubmed |
| spellingShingle | Lighting Up Healing: Green Light-Driven Dual Gasotransmitters Release against MRSA Wound Infections. Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao Methicillin-Resistant Staphylococcus aureus Wound Healing Anti-Bacterial Agents Wound Infection Light Nitric Oxide Carbon Monoxide Animals Staphylococcal Infections Rhodamines Microbial Sensitivity Tests Mice Humans Green Light Lighting Up Healing: Green Light-Driven Dual Gasotransmitters Release against MRSA Wound Infections. Hou, Yanyan Wang, Yuze Yang, Ping Shen, Zhetao Wang, Xueli Chen, Jinquan Yang, Youjun Chen, Daijie Qian, Xuhong Luo, Xiao Methicillin-Resistant Staphylococcus aureus Wound Healing Anti-Bacterial Agents Wound Infection Light Nitric Oxide Carbon Monoxide Animals Staphylococcal Infections Rhodamines Microbial Sensitivity Tests Mice Humans Green Light Methicillin-resistant (MRSA) represents a major clinical challenge as a predominant pathogen causing chronic and difficult-to-treat wound infections. Effective strategies that simultaneously combat bacterial infection and promote tissue regeneration are essential yet challenging for managing MRSA-related wound complications. Herein, we report the design of a novel integrated dual-gas release molecular platform, which enable the phototriggered simultaneous release of NO and CO within a single molecular entity, i.e., an acylhydrazine-caged rhodamine (). Green light initiates the cascade release of NO and CO from , with a synchronized fluorescent turn-on signal, serving as an intrinsic calibration mechanism for real-time tracking of the localization, kinetics of dual gas release. The photodriven simultaneous release of NO and CO from demonstrates a superior antimicrobial effect against MRSA, while exhibiting excellent biocompatibility. By harnessing the synergistic and complementary bioactivities of NO and CO, effectively eradicates bacterial infections and promotes wound healing in a marine MRSA-infected skin wound model. This work highlights a promising noninvasive strategy for multigas simultaneous release therapy, providing a potent approach to tackling resistant bacterial infections and addressing broader biomedical challenges. |
| title | Lighting Up Healing: Green Light-Driven Dual Gasotransmitters Release against MRSA Wound Infections. |
| topic | Methicillin-Resistant Staphylococcus aureus Wound Healing Anti-Bacterial Agents Wound Infection Light Nitric Oxide Carbon Monoxide Animals Staphylococcal Infections Rhodamines Microbial Sensitivity Tests Mice Humans Green Light |
| url | https://pubmed.ncbi.nlm.nih.gov/40711836/ |