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Science advances
2025
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/40712008/ |
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| author | Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien |
| author_facet | Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien |
| collection | PubMed - marine biology |
| contents | Deep homology of a cis-regulatory syntax and the evolutionary origin of the notochord. Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien Notochord T-Box Domain Proteins Fetal Proteins Animals Brachyury Protein Gene Expression Regulation, Developmental Zebrafish Evolution, Molecular Enhancer Elements, Genetic Binding Sites Expression of in the notochord is regarded as a chordate novelty and links to the origin of the notochord, yet the evolution of this regulatory control remains unclear. Here, we uncovered a regulatory syntax (named SFZE) consisting of binding sites for four transcription factors in notochord enhancers of chordate genes. SFZE was also identified in potential enhancers in various non-chordate animals and even in , a unicellular relative to animals. These non-chordate SFZE-containing enhancers exhibited activity in the zebrafish notochord. Furthermore, the SFZE syntax in a non-chordate confers endoderm activity. Our results indicate the ancient association of SFZE with , likely predating the origin of animals. The emergence of notochordal expression could be attributed to co-option of upstream signals acting on the conserved SFZE syntax, which facilitates the origin of the notochord from rudimentary endodermal cells. |
| format | Artículo científico |
| id | pubmed_40712008 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Science advances |
| record_format | pubmed |
| spellingShingle | Deep homology of a cis-regulatory syntax and the evolutionary origin of the notochord. Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien Notochord T-Box Domain Proteins Fetal Proteins Animals Brachyury Protein Gene Expression Regulation, Developmental Zebrafish Evolution, Molecular Enhancer Elements, Genetic Binding Sites Deep homology of a cis-regulatory syntax and the evolutionary origin of the notochord. Fan, Tzu-Pei Lee, Jun-Ru Lin, Che-Yi Chen, Yi-Chih Cutting, Ann E Cameron, R Andrew Yu, Jr-Kai Su, Yi-Hsien Notochord T-Box Domain Proteins Fetal Proteins Animals Brachyury Protein Gene Expression Regulation, Developmental Zebrafish Evolution, Molecular Enhancer Elements, Genetic Binding Sites Expression of in the notochord is regarded as a chordate novelty and links to the origin of the notochord, yet the evolution of this regulatory control remains unclear. Here, we uncovered a regulatory syntax (named SFZE) consisting of binding sites for four transcription factors in notochord enhancers of chordate genes. SFZE was also identified in potential enhancers in various non-chordate animals and even in , a unicellular relative to animals. These non-chordate SFZE-containing enhancers exhibited activity in the zebrafish notochord. Furthermore, the SFZE syntax in a non-chordate confers endoderm activity. Our results indicate the ancient association of SFZE with , likely predating the origin of animals. The emergence of notochordal expression could be attributed to co-option of upstream signals acting on the conserved SFZE syntax, which facilitates the origin of the notochord from rudimentary endodermal cells. |
| title | Deep homology of a cis-regulatory syntax and the evolutionary origin of the notochord. |
| topic | Notochord T-Box Domain Proteins Fetal Proteins Animals Brachyury Protein Gene Expression Regulation, Developmental Zebrafish Evolution, Molecular Enhancer Elements, Genetic Binding Sites |
| url | https://pubmed.ncbi.nlm.nih.gov/40712008/ |